钯催化吡啶氮氧化物与芳基和杂芳基三氟硼酸钾的直接C-H芳基化反应。
Palladium-catalyzed direct C-H arylation of pyridine N-oxides with potassium aryl- and heteroaryltrifluoroborates.
作者信息
Li Mengli, Li Xing, Chang Honghong, Gao Wenchao, Wei Wenlong
机构信息
Taiyuan University of Technology, Department of Chemistry and Chemical Engineering, 79 West Yingze Street, Taiyuan 030024, People's Republic of China.
出版信息
Org Biomol Chem. 2016 Feb 28;14(8):2421-6. doi: 10.1039/c5ob02409a.
PMID:26810705
Abstract
An efficient ligand-free Pd(OAc)2-catalyzed selective arylation of pyridine N-oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C-H bond activation was achieved in the presence of TBAI. This approach has a broad substrate scope and shows moderate to high yields.
摘要
在四丁基碘化铵存在下，实现了一种高效的无配体醋酸钯催化的吡啶氮氧化物选择性芳基化反应，该反应使用（杂）芳基三氟硼酸钾作为偶联伙伴，通过C-H键活化进行。这种方法具有广泛的底物范围，产率为中等至较高。
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