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肾内科医生预测一年内需要透析的准确性如何?

How accurately do nephrologists predict the need for dialysis within one year?

机构信息

Vascular Research Group, Salford Royal Hospital, Manchester Academic Health Sciences Centre, Manchester, UK.

出版信息

Nephron Clin Pract. 2012;122(3-4):102-6. doi: 10.1159/000350730. Epub 2013 Apr 25.

Abstract

BACKGROUND/AIMS: Knowing when patients with chronic kidney disease will need dialysis can improve patient counselling and timing of vascular access. We aimed to assess the accuracy of clinician judgement in predicting the need for dialysis within 12 months.

METHODS

We asked the nephrologists in a dedicated pre-dialysis clinic to predict the time until initiation of dialysis for patients. We compared predicted with actual time to dialysis and the accuracy of predictions made by different grades of clinician. Multivariate logistic regression compared clinical parameters that correlated with predicted and actual time to dialysis.

RESULTS

One hundred and eighty-four patients were included. The sensitivity of clinician judgement as a predictor of dialysis within 12 months was 95% and the specificity was 62%. Consultants were correct in 71% of cases and trainees in 68% of cases. Estimated glomerular filtration rate (eGFR) was the only independent correlate of predicted time to dialysis [odds ratio (OR) = 1.6 per 1 ml/min/1.73 m(2) reduction, p < 0.001]. eGFR was also associated with actual time to dialysis (OR = 1.6 per 1 ml/min/1.73 m(2), p < 0.001) along with age (OR = 0.94 per year increase, p = 0.005) and itch (OR = 3.7, p = 0.048).

CONCLUSION

Clinical judgement is sensitive but not specific in predicting the need for dialysis. Educating the clinicians may improve the specificity of judgement and improve the accuracy of prognostic information given to patients.

摘要

背景/目的:了解慢性肾脏病患者何时需要透析可以改善患者咨询和血管通路的时机。我们旨在评估临床医生判断预测 12 个月内需要透析的准确性。

方法

我们要求专门的透析前诊所的肾病医生预测患者开始透析的时间。我们将预测时间与实际透析时间进行比较,并比较不同级别临床医生的预测准确性。多变量逻辑回归比较了与预测和实际透析时间相关的临床参数。

结果

共纳入 184 例患者。临床医生判断预测 12 个月内透析的敏感性为 95%,特异性为 62%。顾问的准确率为 71%,受训者的准确率为 68%。估计肾小球滤过率(eGFR)是预测透析时间的唯一独立相关因素[比值比(OR)=每减少 1 ml/min/1.73 m2 1.6,p < 0.001]。eGFR 与实际透析时间(OR = 1.6 每 1 ml/min/1.73 m2,p < 0.001)以及年龄(OR = 每年增加 0.94,p = 0.005)和瘙痒(OR = 3.7,p = 0.048)相关。

结论

临床判断在预测透析需求方面具有敏感性但特异性不高。教育临床医生可能会提高判断的特异性,并提高向患者提供预后信息的准确性。

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