Stuart J D, Morgan R F, Kenney J G
Plastic Surgical Group, Tucson, AZ.
Ann Plast Surg. 1990 Jun;24(6):524-7. doi: 10.1097/00000637-199006000-00009.
Early tangential excision sometimes results in considerable blood loss, prolonged operative time, and partial loss of the graft secondary to hematoma formation. Previous reports document positive hemostatic effects and improved skin fixation with fibrin "glue." The commercial preparation used in Europe, however, has not been approved by the United States Food and Drug Administration because of the high risk of hepatitis and human immunodeficiency virus transmission. Using a method developed at the University of Virginia, we applied single-donor fibrin glue as an adjunct in early excision and grafting in 16 patients (26 hands). The overall graft take was 99%. In all patients, better adherence of the split-thickness graft to the recipient bed, during and immediately after application, was noted. We have observed no negative effects with regard to infection or healing. We recommend the use of single-donor fibrin glue to reduce operative blood loss, improve survival and ease of graft application, and possibly to accelerate healing.
早期切线切除有时会导致大量失血、手术时间延长以及由于血肿形成导致移植物部分丢失。先前的报告记录了纤维蛋白“胶水”的积极止血作用和改善的皮肤固定效果。然而，欧洲使用的商业制剂由于存在肝炎和人类免疫缺陷病毒传播的高风险，尚未获得美国食品药品监督管理局的批准。我们采用弗吉尼亚大学开发的一种方法，将单供体纤维蛋白胶水作为辅助手段应用于16例患者（26只手）的早期切除和植皮手术中。总体植皮成活率为99%。在所有患者中，均观察到在应用过程中和应用后即刻，中厚皮片与受区床的黏附性更好。我们未观察到关于感染或愈合方面的负面影响。我们建议使用单供体纤维蛋白胶水以减少手术失血、提高移植物成活率和应用的便利性，并可能加速愈合。
