Hanriat C, Barani C, Mojallal A, Braye F, Brosset S
Centre de Traitement des Brûlés Pierre Colson, Hôpital Édouard Herriot, Lyon, France.
Service de Chirurgie Plastique, Esthétique et Reconstructrice, Hôpital de la Croix Rousse, Lyon, France.
Ann Burns Fire Disasters. 2021 Mar 31;34(1):33-41.
Platelet rich plasma (PRP) has trophic functions due to a high concentration of growth factors and cytokines. These properties may be of therapeutic interest in the management of burn injuries. In preparation for a clinical study at the Lyon Burn Centre on PRP as an inducer of healing in burns, we carried out a review of the literature looking at the results of the use of this therapy. A review of the literature on the use of PRP for the treatment of burn injuries was performed by querying the PUBMED database using the keywords [platelet rich plasma] AND [burns]. Controlled clinical or pre-clinical studies in English or French were included. Eleven articles were identified, consisting of eight preclinical animal model studies and three clinical studies. These looked at the effects of PRP on the healing of burned areas whether they were grafted or not, on the improvement of neuropathic pain, and on distant skin trophicity. The results of recent preclinical studies show shorter epithelialization times thanks to PRP. In humans, a significant study (201 patients) validates its use in combination with thin skin grafts, and another shows benefits on distant cutaneous trophicity. In conclusion, the use of PRP topically or by injection under the skin has a potential benefit in the management of acute burns. A large-scale series validates its use in clinical practice.
富血小板血浆(PRP)因其高浓度的生长因子和细胞因子而具有营养功能。这些特性在烧伤治疗中可能具有治疗价值。为准备在里昂烧伤中心开展一项关于PRP作为烧伤愈合诱导剂的临床研究,我们对相关文献进行了回顾,以了解该疗法的使用结果。通过使用关键词[富血小板血浆]和[烧伤]查询PUBMED数据库,对使用PRP治疗烧伤的文献进行了回顾。纳入了英文或法文的对照临床或临床前研究。共识别出11篇文章,其中包括8篇临床前动物模型研究和3篇临床研究。这些研究探讨了PRP对烧伤区域愈合的影响,无论烧伤区域是否进行了植皮,还探讨了PRP对神经性疼痛改善以及对远处皮肤营养状况的影响。近期临床前研究结果表明,PRP可缩短上皮化时间。在人类研究中,一项重要研究(201例患者)证实了其与薄皮移植联合使用的有效性,另一项研究表明其对远处皮肤营养状况有益。总之,局部使用或皮下注射PRP在急性烧伤治疗中具有潜在益处。一项大规模系列研究证实了其在临床实践中的应用价值。