Centre of Clinical Neuroscience, Department of Neurology, University Hospital Carl Gustav Carus at the Technische Universität Dresden, Germany.
Mult Scler. 2013 Nov;19(13):1792-9. doi: 10.1177/1352458513485655. Epub 2013 May 1.
Multiple sclerosis (MS) is associated with high rates of early retirement (ER).
A German cohort of MS patients and healthy control subjects (HCs) were compared cross-sectionally to investigate disease- and non-disease-specific factors that are associated with employment status (ES) in MS and to identify predictors of ES in MS.
A total of 39 ER MS patients, 48 employed MS patients, and 37 HCs completed a brief neuropsychological battery and questionnaires related to depressive symptoms, fatigue, health-related quality of life (HrQoL) and health locus of control (HLC). Neurological disability was assessed by the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC).
ER compared with employed MS patients scored significantly higher in neurological disability, depressive symptoms and fatigue and significantly lower in cognitive functioning and HrQoL. Further, both groups differed with regard to age, education, disease course and duration but not in HLC. Neurological disability, age and fatigue were identified as significant predictors of ES in MS.
ES in MS was associated with demographic aspects, neurological and cognitive status, depressive symptoms, fatigue and HrQoL but was not associated with HLC. Findings confirm neurological disability, age and fatigue as independent predictors of ES in MS.
多发性硬化症（MS）与早期退休（ER）的高发病率有关。
本研究通过对德国 MS 患者和健康对照组（HCs）进行横断面比较，旨在探讨与 MS 就业状况（ES）相关的疾病和非疾病特异性因素，并确定 MS 中 ES 的预测因素。
共有 39 名 ER MS 患者、48 名在职 MS 患者和 37 名 HCs 完成了简短的神经心理学测试和与抑郁症状、疲劳、健康相关生活质量（HrQoL）和健康控制源（HLC）相关的问卷。神经残疾通过扩展残疾状况量表（EDSS）和多发性硬化功能综合量表（MSFC）进行评估。
与在职 MS 患者相比，ER 患者的神经残疾、抑郁症状和疲劳评分显著更高，认知功能和 HrQoL 显著更低。此外，两组在年龄、教育、病程和持续时间方面存在差异，但在 HLC 方面没有差异。神经残疾、年龄和疲劳是 MS 中 ES 的显著预测因素。
MS 中的 ES 与人口统计学方面、神经和认知状况、抑郁症状、疲劳和 HrQoL 相关，但与 HLC 无关。研究结果证实，神经残疾、年龄和疲劳是 MS 中 ES 的独立预测因素。
