Khutsishvili Natalia, Nikoleishvili Elza, Beruchashvili Tina, Toidze Otar, Megrelishvili Marika, Ganugrava Nino
School of Health Sciences and Public Health, University of Georgia, Tbilisi, GEO.
School of Medicine, Ilia State University, Tbilisi, GEO.
Cureus. 2024 Nov 17;16(11):e73881. doi: 10.7759/cureus.73881. eCollection 2024 Nov.
Multiple sclerosis (MS) significantly impacts health-related quality of life (HRQOL). The Multiple Sclerosis Quality of Life-54 (MSQOL-54) is a widely used tool for assessing HRQOL in individuals with MS. Adapting this tool to the local language and culture is essential for ensuring cultural relevance, enabling comprehensive care, and allowing international comparability. This study aims to validate the Georgian version of the MSQOL-54 (MSQOL-54 GEO) and assess HRQOL in MS patients in Georgia.
A cross-sectional study was conducted, involving 384 individuals with MS. The MSQOL-54 questionnaire was translated using a forward-backward translation technique. Statistical analysis, performed using SPSS 22.0, included internal consistency reliability measured by Cronbach's alpha coefficient (α) with 95% confidence intervals (95% CI), while external validity was determined through the correlation of individual components and composite scores with the Expanded Disability Status Scale (EDSS).
The MSQOL-54-GEO demonstrated strong validity and reliability, with most components showing Cronbach's alpha values above 0.70, except for the "Social Function" component. The "Health Perceptions" component recorded the lowest average score (47.3 ± 20.0). Significant correlations were found between MS duration and "Physical Health," as well as "Cognitive Function."
The findings indicate that the MSQOL-54-GEO is a reliable, convenient, and accepted tool for assessing HRQOL among MS patients in Georgia. This validation contributes valuable insights into the internal consistency of the MSQOL-54-GEO, facilitating its essential use in clinical practice and research, for evaluating treatment outcomes and guiding holistic care approaches, encompassing physical, emotional, and social well-being.
多发性硬化症（MS）对健康相关生活质量（HRQOL）有显著影响。多发性硬化症生活质量-54量表（MSQOL-54）是评估MS患者HRQOL的广泛使用的工具。将该工具适用于当地语言和文化对于确保文化相关性、实现全面护理以及进行国际比较至关重要。本研究旨在验证MSQOL-54的格鲁吉亚语版本（MSQOL-54 GEO）并评估格鲁吉亚MS患者的HRQOL。
进行了一项横断面研究，纳入384例MS患者。采用前后翻译技术对MSQOL-54问卷进行翻译。使用SPSS 22.0进行统计分析，包括用Cronbach's α系数（α）及95%置信区间（95%CI）测量的内部一致性信度，而外部效度则通过各单个分量与综合得分和扩展残疾状态量表（EDSS）之间的相关性来确定。
MSQOL-54-GEO显示出很强的效度和信度，除“社会功能”分量外，大多数分量的Cronbach's α值高于0.70。“健康认知”分量的平均得分最低（47.3±20.0）。发现MS病程与“身体健康”以及“认知功能”之间存在显著相关性。
研究结果表明，MSQOL-54-GEO是评估格鲁吉亚MS患者HRQOL的可靠、便捷且被认可的工具。这一验证为MSQOL-54-GEO的内部一致性提供了有价值的见解，有助于其在临床实践和研究中用于评估治疗效果以及指导涵盖身体、情感和社会福祉的整体护理方法。
