Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Neurology. 2013 May 28;80(22):2076-8. doi: 10.1212/WNL.0b013e318294b2eb. Epub 2013 May 1.
Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is increasing recognition of clinicopathologic variants of PSP.(1.)
进行性核上性麻痹(PSP)是一种相对常见的神经退行性tau 病,临床上以帕金森病、轴性僵硬和核上性眼球运动障碍为特征。PSP 的病理发现是基底节、间脑和脑干中的神经元丧失、神经胶质增生和神经纤维缠结;对 PSP 的临床病理变异越来越认识。(1.)