Josephs Keith A, Mandrekar Jayawant N, Dickson Dennis W
Department of Neurology, Mayo Clinic Rochester, MN, USA.
Parkinsonism Relat Disord. 2006 Mar;12(2):109-12. doi: 10.1016/j.parkreldis.2005.08.007. Epub 2005 Dec 6.
Progressive supranuclear palsy (PSP) is a distinct clinicopathological entity characterized by neurofibrillary tangles, tufted astrocytes, threads and oligodendroglial coiled bodies. These four lesions are distributed in varying densities throughout subcortical and brainstem structures. There is no data regarding the relationship of disease duration to lesion burden severity in PSP. We report the results of analysis of semiquantitative data collected as part of the diagnostic evaluation on 97 cases of 'pure' PSP, submitted to the Society of PSP Brain Bank. Surprisingly, the data suggests that in PSP as duration of illness increases there is a decrease in oligodendroglial tau burden.
进行性核上性麻痹（PSP）是一种独特的临床病理实体，其特征为神经原纤维缠结、簇状星形胶质细胞、细丝和少突胶质细胞卷曲体。这四种病变以不同密度分布于整个皮质下和脑干结构中。目前尚无关于PSP疾病持续时间与病变负荷严重程度之间关系的数据。我们报告了对提交给PSP脑库协会的97例“纯”PSP诊断评估中收集的半定量数据的分析结果。令人惊讶的是，数据表明在PSP中，随着病程延长，少突胶质细胞tau蛋白负荷会降低。
