Brain Research Institute, University of Zurich, Switzerland.
Physiology (Bethesda). 2013 May;28(3):151-63. doi: 10.1152/physiol.00052.2012.
Nogo-A was initially discovered as a myelin-associated growth inhibitory protein limiting axonal regeneration after central nervous system (CNS) injury. This review summarizes current knowledge on how myelin and neuronal Nogo-A and its receptors exert physiological functions ranging from the regulation of growth suppression to synaptic plasticity in the developing and adult intact CNS.
Nogo-A 最初被发现是一种与髓鞘相关的生长抑制蛋白，可限制中枢神经系统 (CNS) 损伤后的轴突再生。本文综述了目前关于髓鞘和神经元 Nogo-A 及其受体如何发挥生理功能的知识，这些功能范围从发育中和成熟完整 CNS 中的生长抑制调节到突触可塑性。
