Department of Physiology, The University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Physiology (Bethesda). 2013 May;28(3):172-89. doi: 10.1152/physiol.00055.2012.
Large-conductance Ca2+ -and voltage-gated K+ channels are activated by an increase in intracellular Ca2+ concentration and/or depolarization. The channel activation mechanism is well described by an allosteric model encompassing the gate, voltage sensors, and Ca2+ sensors, and the model is an excellent framework to understand the influences of auxiliary β and γ subunits and regulatory factors such as Mg2+. Recent advances permit elucidation of structural correlates of the biophysical mechanism.
大电导钙激活钾通道和电压门控钾通道的激活是由细胞内钙离子浓度的增加和/或去极化引起的。通道激活机制很好地描述了变构模型，包括门控、电压传感器和钙离子传感器，该模型是理解辅助β和γ亚基以及调节因子（如 Mg2+）影响的优秀框架。最近的进展使生物物理机制的结构相关性得以阐明。
