• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?

作者信息

Hoshi Toshinori, Armstrong Clay M

机构信息

Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

出版信息

J Gen Physiol. 2013 Feb;141(2):151-60. doi: 10.1085/jgp.201210888. Epub 2013 Jan 14.

DOI:10.1085/jgp.201210888
PMID:23319730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3557304/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/c95051c8cf0f/JGP_201210888_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/adbbdca64fb8/JGP_201210888_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/62a2b26970a9/JGP_201210888_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/df092a88b28e/JGP_201210888_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/c95051c8cf0f/JGP_201210888_Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/adbbdca64fb8/JGP_201210888_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/62a2b26970a9/JGP_201210888_Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/df092a88b28e/JGP_201210888_Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1bc/3557304/c95051c8cf0f/JGP_201210888_Fig4.jpg

相似文献

1
C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?电压门控钾通道的C型失活：孔道收缩还是扩张？
J Gen Physiol. 2013 Feb;141(2):151-60. doi: 10.1085/jgp.201210888. Epub 2013 Jan 14.
2
A structural interpretation of voltage-gated potassium channel inactivation.电压门控钾通道失活的结构解释
Prog Biophys Mol Biol. 2006 Oct;92(2):185-208. doi: 10.1016/j.pbiomolbio.2005.10.001. Epub 2005 Nov 8.
3
Constitutive inactivation of the hKv1.5 mutant channel, H463G, in K+-free solutions at physiological pH.在生理pH值的无钾溶液中，hKv1.5突变通道H463G的组成性失活。
Cell Biochem Biophys. 2005;43(2):221-30. doi: 10.1385/CBB:43:2:221.
4
Voltage-gated ion channels.电压门控离子通道
Curr Biol. 2005 Jan 26;15(2):R44-7. doi: 10.1016/j.cub.2004.12.050.
5
The HERG K+ channel: progress in understanding the molecular basis of its unusual gating kinetics.HERG钾离子通道：在理解其异常门控动力学分子基础方面的进展
Eur Biophys J. 2004 Apr;33(2):89-97. doi: 10.1007/s00249-003-0338-3. Epub 2003 Sep 10.
6
Models of the structure and voltage-gating mechanism of the shaker K+ channel.果蝇钾通道的结构及电压门控机制模型。
Biophys J. 2004 Oct;87(4):2116-30. doi: 10.1529/biophysj.104.040618.
7
KvAP-based model of the pore region of shaker potassium channel is consistent with cadmium- and ligand-binding experiments.基于KvAP的震荡器钾通道孔区模型与镉结合及配体结合实验结果相符。
Biophys J. 2005 Aug;89(2):1020-9. doi: 10.1529/biophysj.105.062240. Epub 2005 May 20.
8
Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating.电压门控钾通道：选择性与门控的结构研究
Cold Spring Harb Perspect Biol. 2016 May 2;8(5):a029231. doi: 10.1101/cshperspect.a029231.
9
Architecture and gating of Hv1 proton channels.Hv1 质子通道的结构与门控。
J Physiol. 2009 Nov 15;587(Pt 22):5325-9. doi: 10.1113/jphysiol.2009.180265.
10
Voltage sensing in ion channels: mesoscale simulations of biological devices.离子通道中的电压传感：生物器件的中尺度模拟
Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jul;86(1 Pt 1):011910. doi: 10.1103/PhysRevE.86.011910. Epub 2012 Jul 11.

引用本文的文献

1
Structure of the human TWIK-2 potassium channel and its inhibition by pimozide.人TWIK-2钾通道的结构及其受匹莫齐特的抑制作用。
Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2425709122. doi: 10.1073/pnas.2425709122. Epub 2025 May 9.
2
Plural molecular and cellular mechanisms of pore domain encephalopathy.孔域脑病的多种分子和细胞机制。
Elife. 2025 Jan 6;13:RP91204. doi: 10.7554/eLife.91204.
3
N-Type Inactivation Variances in Honeybee and Asian Giant Hornet Kv Channels.蜜蜂和亚洲大黄蜂钾离子通道中的N型失活差异

本文引用的文献

1
Mechanism of Cd2+ coordination during slow inactivation in potassium channels.钾通道缓慢失活过程中 Cd2+ 配位的机制。
Structure. 2012 Aug 8;20(8):1332-42. doi: 10.1016/j.str.2012.03.027. Epub 2012 Jul 5.
2
Mechanism of voltage gating in potassium channels.钾通道电压门控机制。
Science. 2012 Apr 13;336(6078):229-33. doi: 10.1126/science.1216533.
3
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals.突变稳定了欧文氏菌属伴刀豆球蛋白 A 门控离子通道的开放状态，但未能改变晶体中孔道结构域的构象。
Bioelectricity. 2022 Sep 8;4(3):145-152. doi: 10.1089/bioe.2022.0006. eCollection 2022 Sep.
4
Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel.在海兔 Kv1 通道中 N 型失活的稳定性和 N 型与 C 型失活的偶联。
Pflugers Arch. 2024 Oct;476(10):1493-1516. doi: 10.1007/s00424-024-02982-5. Epub 2024 Jul 15.
5
C-type inactivation and proton modulation mechanisms of the TASK3 channel.TASK3 通道的 C 型失活和质子调控机制。
Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2320345121. doi: 10.1073/pnas.2320345121. Epub 2024 Apr 17.
6
Dilation of ion selectivity filters in cation channels.阳离子通道中离子选择性过滤器的扩张。
Trends Biochem Sci. 2024 May;49(5):417-430. doi: 10.1016/j.tibs.2024.02.004. Epub 2024 Mar 20.
7
Plural molecular and cellular mechanisms of pore domain encephalopathy.孔结构域脑病的多种分子和细胞机制。
bioRxiv. 2024 Jun 26:2024.01.04.574177. doi: 10.1101/2024.01.04.574177.
8
Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels.揭示哺乳动物 Kv1 通道中 C 型失活的亚型依赖性易感性。
Biophys J. 2024 Jul 16;123(14):2012-2023. doi: 10.1016/j.bpj.2023.12.022. Epub 2023 Dec 28.
9
Eukaryotic Kv channel Shaker inactivates through selectivity filter dilation rather than collapse.真核 Kv 通道 Shaker 通过选择性滤器扩张而不是塌陷失活。
Sci Adv. 2023 Dec 8;9(49):eadj5539. doi: 10.1126/sciadv.adj5539.
10
Structure of the voltage-gated potassium channel K1.3: Insights into the inactivated conformation and binding to therapeutic leads.电压门控钾通道 K1.3 的结构：失活构象的深入了解及与治疗先导物的结合。
Channels (Austin). 2023 Dec;17(1):2253104. doi: 10.1080/19336950.2023.2253104.
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6331-6. doi: 10.1073/pnas.1119268109. Epub 2012 Apr 2.
4
Thermodynamic coupling between activation and inactivation gating in potassium channels revealed by free energy molecular dynamics simulations.自由能分子动力学模拟揭示钾通道激活和失活门控之间的热力学偶联。
J Gen Physiol. 2011 Dec;138(6):571-80. doi: 10.1085/jgp.201110670.
5
Probing the transition state of the allosteric pathway of the Shaker Kv channel pore by linear free-energy relations.通过线性自由能关系探究 Shaker Kv 通道孔变构途径的过渡态。
J Mol Biol. 2010 Oct 22;403(2):167-73. doi: 10.1016/j.jmb.2010.08.041. Epub 2010 Sep 8.
6
Structural mechanism of C-type inactivation in K(+) channels.钾离子通道 C 型失活的结构机制。
Nature. 2010 Jul 8;466(7303):203-8. doi: 10.1038/nature09153.
7
Protein structure modeling with MODELLER.使用MODELLER进行蛋白质结构建模。
Methods Mol Biol. 2008;426:145-59. doi: 10.1007/978-1-60327-058-8_8.
8
Principles underlying energetic coupling along an allosteric communication trajectory of a voltage-activated K+ channel.电压激活钾通道变构通讯轨迹上能量偶联的潜在原理。
Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19813-8. doi: 10.1073/pnas.0708120104. Epub 2007 Dec 5.
9
Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.脂质膜样环境中电压依赖性钾离子通道的原子结构。
Nature. 2007 Nov 15;450(7168):376-82. doi: 10.1038/nature06265.
10
A quantitative description of KcsA gating II: single-channel currents.KcsA通道门控II的定量描述：单通道电流
J Gen Physiol. 2007 Nov;130(5):479-96. doi: 10.1085/jgp.200709844. Epub 2007 Oct 15.