Sathiyamoorthy Srividya, Maleki Zahra
Department of Pathology, Division of Cytopathology, The Johns Hopkins Hospital, Baltimore, Maryland.
Diagn Cytopathol. 2014 Jan;42(1):5-10. doi: 10.1002/dc.22997. Epub 2013 May 2.
Thyroid carcinomas and lung adenocarcinoma share cytomorphological features yet have different prognoses. Thyroid Transcription Factor-1 (TTF-1) is an immunohistochemical (IHC) marker used to confirm pulmonary and thyroid carcinoma, while Thyroglobulin (TGB) is expressed by thyroid carcinoma. The cytopathology archive of The Johns Hopkins Hospital was searched for cases of lung adenocarcinoma versus thyroid carcinoma with TTF-1 and TGB IHC. Forty-four cases of lung adenocarcinoma (25) and thyroid carcinoma (19) were retrieved. One was metastatic lung adenocarcinoma to the thyroid and three were metastatic papillary thyroid carcinoma (PTC) to the lung. The initial interpretation of two cases from bony lesions was metastatic lung adenocarcinoma. In light of additional clinical information and TGB immunostain, the diagnoses of these two cases changed to metastatic thyroid carcinoma. TTF-1 and TGB is a small immunostain panel that can differentiate lung adenocarcinoma from thyroid carcinoma and prevent misdiagnosis and its consequences.
甲状腺癌和肺腺癌具有共同的细胞形态学特征，但预后不同。甲状腺转录因子-1（TTF-1）是一种用于确诊肺癌和甲状腺癌的免疫组织化学（IHC）标志物，而甲状腺球蛋白（TGB）由甲状腺癌表达。检索约翰霍普金斯医院的细胞病理学档案，查找有TTF-1和TGB IHC检测结果的肺腺癌与甲状腺癌病例。共检索到44例病例，其中肺腺癌25例，甲状腺癌19例。1例为肺腺癌转移至甲状腺，3例为甲状腺乳头状癌（PTC）转移至肺。最初对2例骨病变病例的诊断为肺腺癌转移。根据更多临床信息和TGB免疫染色结果，这2例病例的诊断改为甲状腺癌转移。TTF-1和TGB是一个小型免疫染色组合，可区分肺腺癌和甲状腺癌，防止误诊及其后果。
