Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA.
Am J Physiol Regul Integr Comp Physiol. 2013 Jul 15;305(2):R92-4. doi: 10.1152/ajpregu.00191.2013. Epub 2013 May 1.
Numerous studies indicate that renin is synthesized and secreted by the collecting duct (CD). CD-derived renin may act directly on intercalated and/or principal cells through direct interaction with prorenin receptors and/or through cleavage of proximal tubule-derived angiotensinogen to ultimately produce angiotensin II and activate AT1 receptors. Preliminary studies suggest that the net effect of CD renin would be to increase distal nephron salt reabsorption and increase blood pressure. CD renin production is markedly increased in diabetes and angiotensin II-induced hypertension, suggesting that this system may exert pathophysiological effects. In this brief review, we summarize the current literature on synthesis and regulation of CD renin and consider potential mechanisms by which it regulates blood pressure.
大量研究表明，肾素是由集合管（CD）合成和分泌的。CD 来源的肾素可能通过与原肾素受体的直接相互作用和/或通过切割近端小管来源的血管紧张素原，直接作用于闰细胞和/或主细胞，最终产生血管紧张素 II 并激活 AT1 受体。初步研究表明，CD 肾素的净效应将增加远端肾单位的盐重吸收并升高血压。糖尿病和血管紧张素 II 诱导的高血压中 CD 肾素的产生明显增加，表明该系统可能发挥病理生理作用。在这篇简短的综述中，我们总结了关于 CD 肾素合成和调节的当前文献，并考虑了其调节血压的潜在机制。
