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原肾素受体切割位点的突变可消除血管紧张素 II 诱导的小鼠高血压。

Mutagenesis of the Cleavage Site of Pro Renin Receptor Abrogates Angiotensin II-Induced Hypertension in Mice.

机构信息

Department of Internal Medicine, University of Utah and Veterans Affairs Medical Center, Salt Lake City, Utah, United States.

出版信息

Hypertension. 2021 Jul;78(1):115-127. doi: 10.1161/HYPERTENSIONAHA.121.16770. Epub 2021 May 24.

DOI:10.1161/HYPERTENSIONAHA.121.16770
PMID:34024121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9212214/
Abstract

[Figure: see text].

摘要

[图:见正文]。

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本文引用的文献

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Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice.位点 1 蛋白酶衍生的可溶性(前)肾素受体促进小鼠血管紧张素 II 诱导的高血压。
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2
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Placenta. 2020 Nov;101:49-56. doi: 10.1016/j.placenta.2020.08.019. Epub 2020 Aug 23.
3
Soluble (pro)renin receptor treats metabolic syndrome in mice with diet-induced obesity via interaction with PPARγ.可溶性(前)肾素受体通过与 PPARγ 相互作用治疗饮食诱导肥胖小鼠的代谢综合征。
JCI Insight. 2020 Apr 9;5(7):128061. doi: 10.1172/jci.insight.128061.
4
Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.可溶性(前)肾素受体调节 ENaC 参与培养的集合管细胞中的醛固酮信号传导。
Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F817-F825. doi: 10.1152/ajprenal.00436.2019. Epub 2019 Dec 16.
5
The (pro)renin receptor in health and disease.在健康和疾病中的(前)肾素受体。
Nat Rev Nephrol. 2019 Nov;15(11):693-712. doi: 10.1038/s41581-019-0160-5.
6
Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability.站点 1 蛋白酶衍生的可溶性(前)肾素受体靶向血管加压素受体 2 以增强尿液浓缩能力。
JCI Insight. 2019 Apr 4;4(7). doi: 10.1172/jci.insight.124174.
7
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J Clin Hypertens (Greenwich). 2018 Oct;20(10):1377-1391. doi: 10.1111/jch.13364. Epub 2018 Sep 8.
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Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F521-F534. doi: 10.1152/ajprenal.00029.2018. Epub 2018 Apr 18.
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Enzymatic sources and physio-pathological functions of soluble (pro)renin receptor.可溶性(原)肾素受体的酶源及其生理病理功能。
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(Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells.(Pro) 肾素受体介导白蛋白诱导的细胞反应:位点 1 蛋白酶衍生的可溶性 (pro) 肾素受体在肾上皮细胞中的作用。
Am J Physiol Cell Physiol. 2017 Dec 1;313(6):C632-C643. doi: 10.1152/ajpcell.00006.2017. Epub 2017 Sep 13.