• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

耐阿莫西林-克拉维酸的大肠杆菌的流行病学和临床复杂性。

Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli.

机构信息

Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.

出版信息

J Clin Microbiol. 2013 Jul;51(7):2414-7. doi: 10.1128/JCM.00999-13. Epub 2013 May 1.

DOI:10.1128/JCM.00999-13
PMID:23637303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3697715/
Abstract

Two hundred twelve patients with colonization/infection due to amoxicillin-clavulanate (AMC)-resistant Escherichia coli were studied. OXA-1- and inhibitor-resistant TEM (IRT)-producing strains were associated with urinary tract infections, while OXA-1 producers and chromosomal AmpC hyperproducers were associated with bacteremic infections. AMC resistance in E. coli is a complex phenomenon with heterogeneous clinical implications.

摘要

对 212 例因耐阿莫西林克拉维酸（AMC）的大肠埃希菌定植/感染的患者进行了研究。产 OXA-1 和抑制剂耐药 TEM（IRT）的菌株与尿路感染有关，而产 OXA-1 的菌株和染色体 AmpC 超产株与菌血症感染有关。大肠埃希菌对 AMC 的耐药性是一种具有不同临床意义的复杂现象。

相似文献

1
Epidemiological and clinical complexity of amoxicillin-clavulanate-resistant Escherichia coli.耐阿莫西林-克拉维酸的大肠杆菌的流行病学和临床复杂性。
J Clin Microbiol. 2013 Jul;51(7):2414-7. doi: 10.1128/JCM.00999-13. Epub 2013 May 1.
2
Inhibitor-resistant TEM- and OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates.对阿莫西林-克拉维酸耐药的产抑制剂耐药性TEM和OXA-1的大肠杆菌分离株比敏感临床分离株更具克隆性，且毒力基因含量更低。
Antimicrob Agents Chemother. 2014 Jul;58(7):3874-81. doi: 10.1128/AAC.02738-13. Epub 2014 Apr 28.
3
De-escalation for amoxicillin-susceptible Escherichia coli: easier said than done.对于阿莫西林敏感的大肠杆菌进行降阶梯治疗：说起来容易做起来难。
J Hosp Infect. 2010 Mar;74(3):304-5. doi: 10.1016/j.jhin.2009.07.013. Epub 2009 Sep 25.
4
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.西班牙多中心研究大肠杆菌中产β-内酰胺酶株对阿莫西林-克拉维酸耐药的流行病学和机制
Antimicrob Agents Chemother. 2012 Jul;56(7):3576-81. doi: 10.1128/AAC.06393-11. Epub 2012 Apr 9.
5
Exploring the genetic mechanisms underlying amoxicillin-clavulanate resistance in waterborne Escherichia coli.探索水生型大肠杆菌对阿莫西林-克拉维酸耐药性的遗传机制。
Infect Genet Evol. 2021 Jun;90:104767. doi: 10.1016/j.meegid.2021.104767. Epub 2021 Feb 11.
6
Variety of beta-lactamases produced by amoxicillin-clavulanate-resistant Escherichia coli isolated in the northeastern United States.在美国东北部分离出的对阿莫西林-克拉维酸耐药的大肠埃希菌产生的多种β-内酰胺酶。
Antimicrob Agents Chemother. 2004 May;48(5):1520-5. doi: 10.1128/AAC.48.5.1520-1525.2004.
7
Cefotaxime and Amoxicillin-Clavulanate Synergism against Extended-Spectrum-β-Lactamase-Producing Escherichia coli in a Murine Model of Urinary Tract Infection.头孢噻肟与阿莫西林-克拉维酸对产超广谱β-内酰胺酶大肠埃希菌在小鼠尿路感染模型中的协同作用。
Antimicrob Agents Chemother. 2015 Nov 2;60(1):424-30. doi: 10.1128/AAC.02018-15. Print 2016 Jan.
8
Treatment of lower urinary tract infection caused by multidrug-resistant extended-spectrum-beta-lactamase-producing Escherichia coli with amoxicillin/clavulanate: case report and characterization of the isolate.用阿莫西林/克拉维酸治疗产超广谱β-内酰胺酶的耐多药大肠杆菌引起的下尿路感染：病例报告及分离株特征分析
J Antimicrob Chemother. 2006 Jun;57(6):1262-3. doi: 10.1093/jac/dkl102. Epub 2006 Mar 24.
9
Increased amoxicillin-clavulanic acid resistance in Escherichia coli blood isolates, Spain.西班牙大肠杆菌血液分离株中阿莫西林-克拉维酸耐药性增加
Emerg Infect Dis. 2008 Aug;14(8):1259-62. doi: 10.3201/eid1408.071059.
10
Characterization of Inhibitor-Resistant TEM β-Lactamases and Mechanisms of Fluoroquinolone Resistance in Escherichia coli Isolates.大肠杆菌分离株中耐抑制剂的TEMβ-内酰胺酶的特征及氟喹诺酮耐药机制
Microb Drug Resist. 2015 Oct;21(5):512-5. doi: 10.1089/mdr.2015.0039. Epub 2015 May 6.

引用本文的文献

1
Does selective digestive decontamination (SDD) increase antibiotic resistance? Long-term comparison of two intensive care units (with and without SDD) of the same tertiary hospital.选择性消化道去污染（SDD）是否会增加抗生素耐药性？同一三级医院的两个重症监护病房（有和无 SDD）的长期比较。
Eur J Clin Microbiol Infect Dis. 2024 May;43(5):885-893. doi: 10.1007/s10096-024-04792-0. Epub 2024 Mar 9.
2
Early treatment response to piperacillin/tazobactam in patients with bloodstream infections caused by non-ESBL ampicillin/sulbactam-resistant Escherichia coli: a binational cohort study.哌拉西林/他唑巴坦治疗非产 ESBL 氨苄西林/舒巴坦耐药大肠埃希菌血流感染患者的早期治疗反应：一项跨国队列研究。
Infection. 2023 Dec;51(6):1749-1758. doi: 10.1007/s15010-023-02074-z. Epub 2023 Jul 18.
3
Predictors of inappropriate antimicrobial prescription: Eight-year point prevalence surveys experience in a third level hospital in Spain.不适当抗菌药物处方的预测因素：西班牙一家三级医院八年现患率调查经验
Front Pharmacol. 2022 Oct 10;13:1018158. doi: 10.3389/fphar.2022.1018158. eCollection 2022.
4
Clinical effectiveness and bacteriological eradication of three different Short-COurse antibiotic regimens and single-dose fosfomycin for uncomplicated lower Urinary Tract infections in adult women (SCOUT study): study protocol for a randomised clinical trial.三种不同短期疗程抗生素方案与单次磷霉素治疗成人女性单纯性下尿路感染的临床疗效和细菌学清除率（SCOUT 研究）：一项随机临床试验研究方案。
BMJ Open. 2021 Nov 25;11(11):e055898. doi: 10.1136/bmjopen-2021-055898.
5
Characteristics of gram-negative urinary tract infections caused by extended spectrum beta lactamases: pivmecillinam as a treatment option within South Dublin, Ireland.产超广谱β-内酰胺酶革兰阴性菌所致尿路感染的特征：在爱尔兰都柏林南部将匹美西林作为一种治疗选择
BMC Infect Dis. 2016 Nov 3;16(1):620. doi: 10.1186/s12879-016-1797-3.
6
Bloodstream infections caused by Escherichia coli producing AmpC β-lactamases: epidemiology and clinical features.产AmpC β-内酰胺酶大肠埃希菌引起的血流感染：流行病学与临床特征
Eur J Clin Microbiol Infect Dis. 2016 Dec;35(12):1997-2003. doi: 10.1007/s10096-016-2752-3. Epub 2016 Aug 22.
7
Inhibitor-resistant TEM- and OXA-1-producing Escherichia coli isolates resistant to amoxicillin-clavulanate are more clonal and possess lower virulence gene content than susceptible clinical isolates.对阿莫西林-克拉维酸耐药的产抑制剂耐药性TEM和OXA-1的大肠杆菌分离株比敏感临床分离株更具克隆性，且毒力基因含量更低。
Antimicrob Agents Chemother. 2014 Jul;58(7):3874-81. doi: 10.1128/AAC.02738-13. Epub 2014 Apr 28.

本文引用的文献

1
Virulence profiles of bacteremic extended-spectrum β-lactamase-producing Escherichia coli: association with epidemiological and clinical features.产超广谱β-内酰胺酶肠杆菌科细菌菌血症的毒力特征：与流行病学和临床特征的关系。
PLoS One. 2012;7(9):e44238. doi: 10.1371/journal.pone.0044238. Epub 2012 Sep 7.
2
Changing antibiotic susceptibilities of community-acquired uropathogens in Greece, 2005-2010.希腊社区获得性尿路感染病原体的抗生素药敏性变化，2005-2010 年。
J Microbiol Immunol Infect. 2013 Jun;46(3):202-9. doi: 10.1016/j.jmii.2012.05.012. Epub 2012 Jul 12.
3
Spanish multicenter study of the epidemiology and mechanisms of amoxicillin-clavulanate resistance in Escherichia coli.西班牙多中心研究大肠杆菌中产β-内酰胺酶株对阿莫西林-克拉维酸耐药的流行病学和机制
Antimicrob Agents Chemother. 2012 Jul;56(7):3576-81. doi: 10.1128/AAC.06393-11. Epub 2012 Apr 9.
4
Colonisation and infection due to Enterobacteriaceae producing plasmid-mediated AmpC β-lactamases.产质粒介导 AmpC β-内酰胺酶的肠杆菌科细菌的定植和感染。
J Infect. 2012 Feb;64(2):176-83. doi: 10.1016/j.jinf.2011.11.016. Epub 2011 Nov 23.
5
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance.耐多药、广泛耐药和全耐药细菌：获得性耐药的国际专家临时标准定义建议
Clin Microbiol Infect. 2012 Mar;18(3):268-81. doi: 10.1111/j.1469-0691.2011.03570.x. Epub 2011 Jul 27.
6
Secular trend and risk factors for antimicrobial resistance in Escherichia coli isolates in Switzerland 1997-2007.1997-2007 年瑞士大肠埃希菌分离株对抗菌药物耐药性的长期趋势和危险因素。
Infection. 2009 Dec;37(6):534-9. doi: 10.1007/s15010-009-8457-0.
7
Community infections caused by extended-spectrum beta-lactamase-producing Escherichia coli.产超广谱β-内酰胺酶大肠埃希菌引起的社区感染
Arch Intern Med. 2008 Sep 22;168(17):1897-902. doi: 10.1001/archinte.168.17.1897.
8
Increased amoxicillin-clavulanic acid resistance in Escherichia coli blood isolates, Spain.西班牙大肠杆菌血液分离株中阿莫西林-克拉维酸耐药性增加
Emerg Infect Dis. 2008 Aug;14(8):1259-62. doi: 10.3201/eid1408.071059.
9
CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting.疾病控制与预防中心/国家医疗安全网络（CDC/NHSN）对医疗保健相关感染的监测定义以及急性护理环境中特定类型感染的标准。
Am J Infect Control. 2008 Jun;36(5):309-32. doi: 10.1016/j.ajic.2008.03.002.
10
Surveillance of outpatient antibiotic consumption in Spain according to sales data and reimbursement data.根据销售数据和报销数据对西班牙门诊抗生素消费情况进行监测。
J Antimicrob Chemother. 2007 Sep;60(3):698-701. doi: 10.1093/jac/dkm248. Epub 2007 Jul 6.