Talal N, Dauphinée M J, Dang H, Alexander S S, Hart D J, Garry R F
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7874.
Arthritis Rheum. 1990 Jun;33(6):774-81. doi: 10.1002/art.1780330603.
Primary Sjögren's syndrome (SS) is considered a benign autoimmune disease; it is characterized by lymphoid infiltration of salivary and lacrimal glands, often accompanied by the presence of serum autoantibodies, particularly anti-Ro (SS-A) and anti-La (SS-B). There are important immunologic similarities between primary SS and acquired immunodeficiency syndrome. To investigate for a possible immune response to retroviral proteins in primary SS, we performed immunoblotting against human immunodeficiency virus-1 (HIV-1) proteins using sera from 47 patients with primary SS. Moderate-to-strong reactivity, suggesting the presence of serum antibodies, was found in 14 patients (30%). Of 120 normal subjects, only 1 showed moderate positivity. All 14 positive SS sera reacted against p24 (gag) but failed to react against gp41 or gp120 (env). This response did not reflect hypergammaglobulinemia since immunoglobulin concentrations among the 29 SS patients studied were the same in sera that contained and sera that did not contain anti-gag reactivity. Two sera also reacted against p17 gag. Four reacted against HIV-2 core proteins, but none reacted with core proteins of human T lymphotropic virus-I. Only 1 of the 14 sera reacted against Ro (SS-A), and 1 other reacted against La (SS-B). These results identify a subset of SS patients characterized by 1) the presence of serum antibodies to HIV-1 group-specific, but not type-specific, proteins, and 2) the relative absence of anti-Ro (SS-A) and anti-La (SS-B) autoantibodies. In this latter respect, these SS patients constitute a subpopulation that resembles patients with HIV-induced SS-like disease.
原发性干燥综合征（SS）被认为是一种良性自身免疫性疾病；其特征为唾液腺和泪腺的淋巴细胞浸润，常伴有血清自身抗体的存在，尤其是抗Ro（SS - A）和抗La（SS - B）抗体。原发性SS与获得性免疫缺陷综合征之间存在重要的免疫学相似性。为了研究原发性SS患者对逆转录病毒蛋白可能产生的免疫反应，我们使用47例原发性SS患者的血清对人类免疫缺陷病毒1型（HIV - 1）蛋白进行了免疫印迹分析。在14例患者（30%）中发现了中度至强反应性，提示存在血清抗体。在120名正常受试者中，只有1人呈中度阳性。所有14份阳性的SS血清均与p24（gag）发生反应，但未与gp41或gp120（env）发生反应。这种反应并不反映高球蛋白血症，因为在所研究的29例SS患者中，含有和不含有抗gag反应性的血清中的免疫球蛋白浓度相同。两份血清还与p17 gag发生反应。四份血清与HIV - 2核心蛋白发生反应，但均未与人嗜T淋巴细胞病毒I型的核心蛋白发生反应。14份血清中只有1份与Ro（SS - A）发生反应，另1份与La（SS - B）发生反应。这些结果确定了一部分SS患者，其特征为：1）存在针对HIV - 1组特异性而非型特异性蛋白的血清抗体；2）相对缺乏抗Ro（SS - A）和抗La（SS - B）自身抗体。在这后一方面，这些SS患者构成了一个类似于HIV诱导的类SS疾病患者的亚群。
