Boucherat Olivier, Boczkowski Jorge, Jeannotte Lucie, Delacourt Christophe
Centre de recherche en cancérologie de l'Université Laval, Centre Hospitalier Universitaire de Québec, Québec, Canada.
Exp Lung Res. 2013 May-Jun;39(4-5):207-16. doi: 10.3109/01902148.2013.791733. Epub 2013 May 3.
The mucociliary system, consisting of mucus-secreting goblet cells and ciliated cells, generates a constant overturning layer of protective mucus that lines the airway epithelium. Mucus hypersecretion and the pathophysiological changes associated are hallmarks of many pulmonary diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. Excessive mucus production leads to airway obstruction and, because there is currently no effective treatment, contributes to morbidity and mortality of many patients. Goblet cell differentiation and mucus production are subject to extensive control. An emerging concept is that not all goblet cells are phenotypically identical suggesting that specific molecular pathways orchestrate mucin overproduction. This paper attempts to describe the cellular and molecular mechanisms governing the differentiation of goblet cells in pulmonary diseases, a prerequisite for the development of new therapeutic agents.
由分泌黏液的杯状细胞和纤毛细胞组成的黏液纤毛系统，会产生一层持续翻转的保护性黏液，覆盖气道上皮。黏液分泌过多以及相关的病理生理变化是许多肺部疾病的特征，包括哮喘、慢性阻塞性肺疾病和囊性纤维化。过多的黏液分泌会导致气道阻塞，并且由于目前尚无有效治疗方法，这导致许多患者发病和死亡。杯状细胞分化和黏液分泌受到广泛调控。一个新出现的概念是，并非所有杯状细胞在表型上都是相同的，这表明特定的分子途径协调了黏蛋白的过度产生。本文试图描述肺部疾病中杯状细胞分化的细胞和分子机制，这是开发新治疗药物的先决条件。
