Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, D-14195 Berlin, Germany.
Neuropsychologia. 2013 Jul;51(8):1649-61. doi: 10.1016/j.neuropsychologia.2013.04.005. Epub 2013 Apr 29.
Using a specific variant of the dichotic listening paradigm, we studied the influence of dopamine on attentional modulation of auditory perception by assessing effects of allelic variation of a single-nucleotide polymorphism (SNP) rs907094 in the DARPP-32 gene (dopamine and adenosine 3', 5'-monophosphate-regulated phosphoprotein 32 kilodations; also known as PPP1R1B) on behavior and cortical evoked potentials. A frequent DARPP-32 haplotype that includes the A allele of this SNP is associated with higher mRNA expression of DARPP-32 protein isoforms, striatal dopamine receptor function, and frontal-striatal connectivity. As we hypothesized, behaviorally the A homozygotes were more flexible in selectively attending to auditory inputs than any G carriers. Moreover, this genotype also affected auditory evoked cortical potentials that reflect early sensory and late attentional processes. Specifically, analyses of event-related potentials (ERPs) revealed that amplitudes of an early component of sensory selection (N1) and a late component (N450) reflecting attentional deployment for conflict resolution were larger in A homozygotes than in any G carriers. Taken together, our data lend support for dopamine's role in modulating auditory attention both during the early sensory selection and late conflict resolution stages.
使用一种特定的双耳分听范式变体，我们通过评估多巴胺和腺苷 3'，5'-单磷酸调节磷蛋白 32 千道尔顿（也称为 PPP1R1B）基因中单个核苷酸多态性（SNP）rs907094 的等位基因变异对听觉感知注意力调节的影响来研究多巴胺的作用。这个 SNP 的 A 等位基因的一种常见 DARPP-32 单倍型与 DARPP-32 蛋白同工型的更高 mRNA 表达、纹状体多巴胺受体功能和额纹状体连接有关。正如我们假设的那样，行为上 A 纯合子比任何 G 携带者更能灵活地选择性注意听觉输入。此外，这种基因型还影响反映早期感觉和晚期注意力过程的听觉诱发皮层电位。具体来说，事件相关电位（ERP）分析表明，反映感觉选择早期成分（N1）和反映注意力分配用于冲突解决的晚期成分（N450）的振幅在 A 纯合子中大于任何 G 携带者。总之，我们的数据支持多巴胺在调节听觉注意力方面的作用，无论是在早期感觉选择还是晚期冲突解决阶段。
