International Agency for Research on Cancer, Lyon, France.
Gastroenterol Clin North Am. 2013 Jun;42(2):219-40. doi: 10.1016/j.gtc.2013.01.003. Epub 2013 Mar 29.
Gastric cancer is one of the major malignancies in the world. This article summarizes the current understanding of the worldwide burden of this disease, its geographic variation, and temporal trends. An overview is presented of known risk factors, including genetic, dietary, and behavioral, but focuses on Helicobacter pylori infection as the most important factor in noncardia gastric cancer. When the data and the literature allow, we distinguish between cardia and noncardia sub-sites, as it is now clear that these two anatomic locations present distinct and sometimes opposite epidemiological characteristics.
胃癌是全球主要的恶性肿瘤之一。本文总结了目前对该病全球负担的认识，包括疾病的地理变异和时间趋势。本文概述了已知的危险因素，包括遗传、饮食和行为因素，但重点介绍了幽门螺杆菌感染作为非贲门胃癌最重要的因素。在数据和文献允许的情况下，我们区分贲门和非贲门亚部位，因为现在已经清楚这两个解剖部位具有不同的、有时甚至相反的流行病学特征。
