Scripps Allergy and Immunology Fellowship Program, Division of Allergy and Immunology, Scripps Clinic, San Diego, CA 92130, USA.
Immunol Allergy Clin North Am. 2013 May;33(2):237-49. doi: 10.1016/j.iac.2012.12.002. Epub 2013 Feb 1.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been implicated in a variety of drug-induced reactions that are proved as or suspected of being mediated through a host immune response. Single-drug-induced reactions are the hallmark of these types of reactions. The types of single-drug-induced reactions are the confluence of 2 variables, the structure of the drug and the specific types of immune responses. This article identifies reactions patterns and the NSAIDs most likely to elicit each immune response.
非甾体抗炎药（NSAIDs）是环氧化酶抑制剂，具有镇痛、抗炎、解热和抗血栓作用。 NSAIDs 与多种药物诱导的反应有关，这些反应已被证明或怀疑是通过宿主免疫反应介导的。 单药诱导的反应是这些类型反应的特征。 单药诱导反应的类型是两种变量的融合，即药物的结构和特定类型的免疫反应。 本文确定了反应模式和最有可能引起每种免疫反应的 NSAIDs。
