Biopolymers and Proteomics Unit, IRCCS AOU San Martino-IST, San Martino University Hospital and National Cancer Research Institute, Genoa, Italy.
J Proteomics. 2013 Jun 24;85:44-52. doi: 10.1016/j.jprot.2013.04.029. Epub 2013 Apr 30.
Gross cystic disease (GCDB) is a breast benign condition predisposing to breast cancer. Cryopreserved sera from GCDB patients, some of whom later developed a cancer (cases), were studied to identify potential risk markers. A MALDI-TOF mass spectrometry analysis found several complement C3f fragments having a significant increased abundance in cases compared to controls. After multivariate analysis, the full-length form of C3f maintained a predictive value of breast cancer risk. Higher levels of C3f in the serum of women affected by a benign condition like GCDB thus appears to be correlated to the development of breast cancer even 20 years later.
Increased complement system activation has been found in the sera of women affected by GCDB who developed a breast cancer, even twenty or more years later. C3f may predict an increased breast cancer risk in the healthy population and in women affected by predisposing conditions.
大囊性病（GCDB）是一种良性乳腺疾病，易患乳腺癌。对患有 GCDB 且后来发生癌症（病例）的患者的冷冻血清进行了研究，以鉴定潜在的风险标志物。MALDI-TOF 质谱分析发现，与对照组相比，病例中几种补体 C3f 片段的丰度显著增加。经过多变量分析，全长形式的 C3f 仍然具有预测乳腺癌风险的价值。因此，在患有 GCDB 等良性疾病的女性的血清中，C3f 水平升高似乎与乳腺癌的发生有关，即使在 20 年后也是如此。
即使在 20 年或更长时间后，患有 GCDB 并发生乳腺癌的女性的血清中发现补体系统激活增加。C3f 可能预测健康人群和易患疾病人群的乳腺癌风险增加。
