双波长光热光学相干断层成像术用于测量微血管血氧饱和度。
Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation.
机构信息
University of Texas at Austin, Departments of Electrical and Computer Engineering, Austin, TX 78712, USA.
出版信息
J Biomed Opt. 2013 May;18(5):56005. doi: 10.1117/1.JBO.18.5.056005.
Abstract
A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation (SO(2)) levels in phantom blood vessels with a range of blood flow speeds (0 to 17 mm/s). A 50-μm-diameter blood vessel phantom is imaged, and SO(2) levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO(2) measurement are identified and investigated.
摘要
一种扫频双波长光热（DWP）光相干断层扫描（OCT）系统，用于定量成像微血管氧饱和度。DWP-OCT 能够记录组织的三维图像和响应光热激发的深度分辨相位变化。1064nm 的 OCT 探头和 770nm 和 800nm 的光热激发光束结合在单模光纤中，以测量具有不同血流速度（0 至 17mm/s）的模拟血管中的微血管血红蛋白氧饱和度（SO₂）水平。对 50μm 直径的血管模拟体进行成像，并使用 DWP-OCT 测量 SO₂ 水平，并与不同血氧浓度下商业血氧计提供的值进行比较。确定并研究了血流速度和 SNR 相位降关键因素对 SO₂ 测量准确性的影响。
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