Karolinska University Laboratory, Department of Clinical Pharmacology, Karolinska University Hospital, Stockholm, Sweden.
Eur J Clin Pharmacol. 2013 May;69 Suppl 1:25-32. doi: 10.1007/s00228-013-1504-x. Epub 2013 May 3.
Therapeutic drug monitoring (TDM) represents an early approach to personalised medicine. It helps the clinician to individualise drug treatment and guide dosage to reach systemic drug concentrations associated with therapeutic efficacy and/or to reduce the risk of concentration-dependent adverse effects. Well into the fifth decade of TDM as a service to healthcare, this concept is still expanding, and new areas for clinical implementation continue to emerge. The aim of this overview is to discuss promising new therapeutic areas in future TDM services, how to improve the clinical interpretation of single drug measurements and how recent technology development opens the doors to research and new applications.
治疗药物监测（therapeutic drug monitoring，TDM）代表了个性化医学的早期方法。它帮助临床医生个体化药物治疗，并指导剂量以达到与治疗效果相关的系统药物浓度，或降低与浓度相关的不良反应的风险。TDM 作为医疗保健服务已经进入第五十个年头，这个概念仍在不断发展，新的临床应用领域不断涌现。本文的目的是讨论未来 TDM 服务中有前途的新治疗领域，如何提高对单一药物测量的临床解释，以及最近的技术发展如何为研究和新应用开辟道路。
