From the Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy.
Clin Nucl Med. 2014 May;39(5):472-4. doi: 10.1097/RLU.0b013e31828da691.
A 42-year-old woman underwent resection of a high-risk melanoma of the right thigh. Adjuvant treatment with ipilimumab was then started within a phase III randomised, double-blind clinical trial. F-FDG PET/CT scan showed intense uptake in mediastinal hilar lymph nodes, bilaterally, and in rectus abdominis muscle. Biopsy at the abdominal wall revealed a chronic granulomatous inflammation. After oral steroid treatment, all the areas of abnormal tracer uptake disappeared. Ipilimumab can induce inflammatory immunomediated reactions that should be taken into account to avoid misinterpretation.
一位 42 岁女性接受了右侧大腿高危黑色素瘤的切除术。随后在一项 III 期随机、双盲临床试验中开始使用伊匹单抗进行辅助治疗。F-FDG PET/CT 扫描显示双侧纵隔肺门淋巴结和腹直肌摄取明显增加。腹壁活检显示慢性肉芽肿性炎症。口服类固醇治疗后，所有异常示踪剂摄取部位均消失。伊匹单抗可诱导炎症性免疫介导反应，应予以考虑，以避免误诊。
