McCormick Zack, Plastaras Christopher
Department of Physical Medicine and Rehabilitation, The Rehabilitation Institute of Chicago/Northwestern University, Chicago, IL, USA.
J Back Musculoskelet Rehabil. 2013;26(2):183-8. doi: 10.3233/BMR-130366.
Current evidence suggests that lumbosacral transforaminal epidural steroid injection (TFESI) is an effective treatment for lumbosacral radicular pain. However, practitioners may be reluctant to attempt this intervention in obese patients because of a perceived reduction in the chance of providing pain relief due to the increased technical difficulty of TFESI in individuals with a larger body habitus. No study to date has compared the effectiveness of TFESI in groups stratified by BMI. We report pilot data addressing whether lumbosacral transforaminal epidural steroid injection is as effective in treating lumbosacral radicular pain in the obese and overweight population as it is in the non-overweight population.
This study consisted of 9 normal weight (18.5 < BMI < 25), 9 overweight (25 < BMI < 30), and 6 obese (BMI > 30) patients who presented with lumbosacral radicular pain and received a TFESI. For each group, percent reduction in pain and the proportion of individuals with a 50% or greater reduction in pain 2-4 weeks after TFESI was determined.
Comparing the overweight and obese groups to the normal weight group, no significant differences were found in the percent improvement in pain after TFESI (p=0.7154, p=0.4566) or in the proportion of each group with a 50% or greater reduction in lower back pain after TFESI (p=0.2968).
Our pilot data indicates that lumbosacral TFESI is as effective in providing short-term relief of lumbosacral radicular pain in obese and overweight patients as it is in non-overweight patients. However, our sample size was not large enough to find a significant difference at a power of 80%. We plan to perform a larger prospective study to confirm the findings of this study.
Case-control study, Level II-2.
目前的证据表明,腰骶部经椎间孔硬膜外类固醇注射(TFESI)是治疗腰骶部神经根性疼痛的有效方法。然而,由于认为肥胖患者因体型较大导致TFESI技术难度增加,从而使缓解疼痛的机会减少,从业者可能不愿对肥胖患者尝试这种干预措施。迄今为止,尚无研究比较按体重指数(BMI)分层的各组中TFESI的有效性。我们报告了关于腰骶部经椎间孔硬膜外类固醇注射在肥胖和超重人群中治疗腰骶部神经根性疼痛是否与非超重人群同样有效的初步数据。
本研究包括9名体重正常(18.5<BMI<25)、9名超重(25<BMI<30)和6名肥胖(BMI>30)的患者,这些患者均表现为腰骶部神经根性疼痛并接受了TFESI治疗。对于每组患者,确定TFESI后2 - 4周疼痛减轻的百分比以及疼痛减轻50%或更多的个体比例。
将超重和肥胖组与体重正常组进行比较,TFESI后疼痛改善百分比(p = 0.7154,p = 0.4566)或TFESI后腰背痛减轻50%或更多的每组个体比例(p = 0.2968)均未发现显著差异。
我们的初步数据表明,腰骶部TFESI在肥胖和超重患者中提供腰骶部神经根性疼痛短期缓解的效果与非超重患者相同。然而,我们的样本量不够大,无法在80%的检验效能下发现显著差异。我们计划进行一项更大规模的前瞻性研究以证实本研究的结果。
病例对照研究,II - 2级。