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男性患者以不典型的卡尼综合征表现为特征的伴有粘蛋白细胞的垂体腺瘤。

Pituitary adenoma with mucin cells in a man with an unusual presentation of Carney complex.

机构信息

Departments of Pathology and Laboratory Medicine and Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

出版信息

Endocr Pathol. 2013 Jun;24(2):106-9. doi: 10.1007/s12022-013-9247-x.

Abstract

We describe a 44-year-old man with infertility, acromegaly, and hypergonadotropic hypogonadism. Clinical examination of the patient revealed hyperpigmented macules on the lips, buccal mucosa, and face which were histologically confirmed as cutaneous myxomas and blue nevi. Ultrasound revealed testicular calcifications and multiple hypoechoic thyroid nodules. MR imaging showed a pituitary microadenoma and resection revealed it to be a growth hormone and prolactin-secreting adenoma with the unusual finding of admixed individual mucin-producing cells. We discuss mucin cells in pituitary adenoma, an unreported pathologic finding in a patient with Carney complex.

摘要

我们描述了一名 44 岁男性,其患有不育症、肢端肥大症和促性腺激素性性腺功能减退症。对患者的临床检查发现嘴唇、颊粘膜和面部有色素沉着的斑块,组织学上证实为皮肤粘液瘤和蓝色痣。超声显示睾丸钙化和多个低回声甲状腺结节。磁共振成像显示垂体微腺瘤,切除后显示为生长激素和催乳素分泌腺瘤,并有罕见的混合个体粘蛋白分泌细胞。我们讨论了垂体腺瘤中的粘蛋白细胞,这是 Carney 综合征患者中未报道的病理发现。

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