Kunnimalaiyaan Muthusamy, Haymart Megan R, Chen Herbert
Endocrine Surgery Research Laboratories, Section of Endocrine Surgery, Department of Surgery, The University of Wisconsin, and the University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, WI, U.S.A.
Transl Oncogenomics. 2007 May 3;2:43-7. Print 2007.
There is a growing body of literature suggesting that signaling based therapy might be a potential approach for medullary thyroid cancer (MTC). In this review we focus on the tumor suppressor role of Notch1 and Raf-1 signaling in MTC. Interestingly these two pathways are minimally active or absent in these tumors and activation of Notch1 and Raf-1 significantly reduces tumor growth in vitro. Therefore, identification of compounds that induce these pathways could be a potential strategy to treat patients with MTC.
越来越多的文献表明,基于信号传导的疗法可能是治疗甲状腺髓样癌(MTC)的一种潜在方法。在本综述中,我们重点关注Notch1和Raf-1信号传导在MTC中的肿瘤抑制作用。有趣的是,这两条通路在这些肿瘤中活性极低或不存在,而Notch1和Raf-1的激活显著降低了体外肿瘤生长。因此,鉴定能诱导这些通路的化合物可能是治疗MTC患者的一种潜在策略。