Reid Debra J, Pham Nga T
Department of Pharmacy Practice, School of Pharmacy, Northeastern University, Boston, MA, USA.
Clin Med Insights Circ Respir Pulm Med. 2013 Apr 9;7:7-15. doi: 10.4137/CCRPM.S8140. Print 2013.
Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide and is projected to be the third by 2020. COPD is characterized by chronic airflow limitation caused by airway inflammation and parenchymal destruction that is usually progressive. Inhaled bronchodilators continue to be the mainstay of the current management of COPD. Safety and efficacy data of the recently approved medications including aclidinium, glycopyrronium, roflumilast, and indacaterol are reviewed here.
慢性阻塞性肺疾病(COPD)是全球第四大致死原因,预计到2020年将成为第三大致死原因。COPD的特征是由气道炎症和通常呈进行性的实质破坏导致的慢性气流受限。吸入性支气管扩张剂仍然是目前COPD治疗的主要手段。本文回顾了最近批准的药物,包括阿地溴铵、格隆溴铵、罗氟司特和茚达特罗的安全性和有效性数据。