Kuznetsov V I
Kosm Biol Aviakosm Med. 1989 Sep-Oct;23(5):78-82.
We examined heart tolerance of rats, that had been exposed to two-month social stress, to acute overload caused by aortic coarctation and investigated physiological doses of thyroid hormones used to treat stress-induced tolerance changes. Cardiac contractility of rats adapted to chronic stress and exposed to overload was similar to that of controls and the functional maximum reached at the 5th second of aortic coarctation was 33-53% higher than that in the controls. However, tolerance of chronically adapted hearts measured by their ability to maintain increased contractility during 25 s aortic coarctation was 1.4-1.8 times lower. Thyroid hormones in physiological doses normalized tolerance of chronically stressed hearts to overload induced by aortic coarctation.
我们研究了经历两个月社会应激的大鼠对主动脉缩窄引起的急性负荷的心脏耐受性，并研究了用于治疗应激诱导的耐受性变化的甲状腺激素的生理剂量。适应慢性应激并暴露于负荷的大鼠的心脏收缩力与对照组相似，主动脉缩窄第5秒时达到的功能最大值比对照组高33%-53%。然而，通过在25秒主动脉缩窄期间维持增加的收缩力的能力来衡量的慢性适应心脏的耐受性低1.4-1.8倍。生理剂量的甲状腺激素使慢性应激心脏对主动脉缩窄诱导的负荷的耐受性恢复正常。
