Klimenko E D, Kobozeva L P, Michunskaia A B, Zolotov N N, Khabarina I Iu, Pozdniakov O M
Biull Eksp Biol Med. 1990 Mar;109(3):234-7.
The effect of antioxidant (AO) of the 3-hydroxypyridin class on microcirculatory system (MC) disorders of rabbits with dyslipoproteinemia (DLP) and its alimentary correction (the standard ration--9 months) was studied. Aorta, the intestinal mesentery microcirculatory bed, the microvessels adrenergic innervation, erythrocyte morphology were examined. The various lipoprotein fractions and lipid peroxidation (LP) products were studied in venous blood. After AO including into atherogenic diet (ATD) the lipid homeostasis disorders, the LP activation, MC disturbances, anomalous erythrocyte form appearance and atherosclerosis changes in aorta were less pronounced. Under the AO influence when DLP was corrected the initial level of lipid metabolism and LP restored, the MC disorders and the atherosclerosis changes in aorta regressed in a shorter period of time. The interrelation was observed between the DLP level, the structural and functional MC disorders and the extent of aorta atherosclerosis. Thus, DLP and LP correction at the early stages of pathological process can lead to the disappearance of MC disorders, what seems important for the prevention of atherosclerosis. The role of the LP activation in MC disorders in DLP and mexidol effect on them, especially in complex with DLP correction were evaluated.
研究了3 - 羟基吡啶类抗氧化剂（AO）对脂蛋白血症（DLP）家兔微循环系统（MC）紊乱及其营养纠正（标准日粮 - 9个月）的影响。检查了主动脉、肠系膜微循环床、微血管肾上腺素能神经支配、红细胞形态。研究了静脉血中的各种脂蛋白组分和脂质过氧化（LP）产物。在将AO纳入致动脉粥样化饮食（ATD）后，脂质稳态紊乱、LP激活、MC紊乱、异常红细胞形态出现以及主动脉粥样硬化变化均不那么明显。在AO影响下，当DLP得到纠正时，脂质代谢和LP的初始水平得以恢复，MC紊乱和主动脉粥样硬化变化在更短时间内消退。观察到DLP水平、MC的结构和功能紊乱与主动脉粥样硬化程度之间的相互关系。因此，在病理过程早期纠正DLP和LP可导致MC紊乱消失，这对预防动脉粥样硬化似乎很重要。评估了LP激活在DLP的MC紊乱中的作用以及美西律对它们的影响，特别是与DLP纠正联合时的影响。
