BC Centre for Excellence in HIV/AIDS, 608-1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
Drug Alcohol Depend. 2013 Oct 1;132(3):535-40. doi: 10.1016/j.drugalcdep.2013.03.024. Epub 2013 May 1.
Needle and syringe programmes (NSPs) have been shown to reduce HIV risk among people who inject drugs (IDUs). However, concerns remain that NSPs delay injecting cessation.
Individuals reporting injection drug use in the past six months in the greater Vancouver area were enrolled in the Vancouver Injection Drug Users Study (VIDUS). Annual estimates of the proportion of IDU reporting injecting cessation were generated. Generalized estimating equation (GEE) analysis was used to assess factors associated with injecting cessation during a period of NSP expansion.
Between May 1996 and December 2010, the number of NSP sites in Vancouver increased from 1 to 29 (P<0.001). The estimated proportion of participants (n=2710) reporting cessation increased from 2.4% (95% confidence interval [CI]: 0.0-7.0%) in 1996 to 47.9% (95% CI: 46.8-48.9%) in 2010 (P<0.001). In a multivariate GEE analysis, the authors observed an association between increasing calendar year and increased likelihood of injecting cessation (Adjusted Odds Ratio=1.17, 95% CI: 1.15, 1.19, P<0.001).
The proportion of IDU reporting injecting cessation increased during a period of NSP expansion, implying that increased NSP availability did not delay injection cessation. These results should help inform community decisions on whether to implement NSPs.
已证实针具交换项目(NSP)可降低注射吸毒者(IDU)的 HIV 感染风险。然而,人们仍然担心 NSP 会延迟注射的终止。
在大温哥华地区,过去六个月有过注射吸毒史的个体被纳入温哥华注射吸毒者研究(VIDUS)。生成 IDU 报告注射终止的年度比例估计值。使用广义估计方程(GEE)分析来评估在 NSP 扩张期间与注射终止相关的因素。
1996 年 5 月至 2010 年 12 月期间,温哥华的 NSP 站点数量从 1 个增加到 29 个(P<0.001)。报告终止的参与者(n=2710)的估计比例从 1996 年的 2.4%(95%置信区间[CI]:0.0-7.0%)增加到 2010 年的 47.9%(95% CI:46.8-48.9%)(P<0.001)。在多变量 GEE 分析中,作者观察到随着日历年份的增加,注射终止的可能性也随之增加(调整后的优势比=1.17,95% CI:1.15,1.19,P<0.001)。
在 NSP 扩张期间,报告注射终止的 IDU 比例增加,这表明增加 NSP 的供应并没有延迟注射的终止。这些结果应该有助于为社区关于是否实施 NSP 的决策提供信息。