Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110-744, Republic of Korea.
Environ Res. 2013 Jul;124:23-7. doi: 10.1016/j.envres.2013.04.001. Epub 2013 May 2.
Toxic heavy metals have adverse effects on human health. However, the risk of hematuria caused by heavy metal exposure has not been evaluated.
Data from 4701 Korean adults were obtained in the Korean National Health and Nutritional Examination Survey (2008-2010). Blood levels of the toxic heavy metals cadmium, lead, and mercury were measured. Hematuria was defined as a result of ≥+1 on a urine dipstick test. The odds ratios (ORs) for hematuria were measured according to the blood heavy metal levels after adjusting for multiple variables.
Individuals with blood cadmium levels in the 3rd and 4th quartiles had a greater OR for hematuria than those in the 1st quartile group: 3rd quartile, 1.35 (1.019-1.777; P=0.037); 4th quartile, 1.52 (1.140-2.017; P=0.004). When blood cadmium was considered as a log-transformed continuous variable, the correlation between blood cadmium and hematuria was significant: OR, 1.97 (1.224-3.160; Ptrend=0.005). In contrast, no significant correlations between hematuria and blood lead or mercury were found in the multivariate analyses.
The present study shows that high cadmium exposure is associated with a risk of hematuria.
有毒重金属对人体健康有不良影响。然而，重金属暴露导致血尿的风险尚未得到评估。
在韩国国家健康和营养检查调查（2008-2010 年）中获得了 4701 名韩国成年人的数据。测量了有毒重金属镉、铅和汞的血液水平。血尿定义为尿试纸检测结果≥+1。在调整多个变量后，根据血液重金属水平测量血尿的比值比（OR）。
血液镉水平处于第 3 四分位数和第 4 四分位的个体发生血尿的 OR 高于第 1 四分位组：第 3 四分位，1.35（1.019-1.777；P=0.037）；第 4 四分位，1.52（1.140-2.017；P=0.004）。当将血液镉视为对数转换的连续变量时，血液镉与血尿之间存在显著相关性：OR，1.97（1.224-3.160；Ptrend=0.005）。相比之下，多元分析未发现血尿与血铅或血汞之间存在显著相关性。
本研究表明，高镉暴露与血尿风险相关。
