Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Int Arch Occup Environ Health. 2013 Jul;86(5):607-13. doi: 10.1007/s00420-012-0796-y. Epub 2012 Jul 6.
We present data from the Korean National Health and Nutrition Examination Survey 2008-2009 regarding the association between blood lead and mercury levels and periodontitis in a representative sample of the adult South Korean population.
The analysis was restricted to participants ≥20 years of age who completed the health examination survey, including blood lead, cadmium, and mercury measurements (n = 3,966). Odds ratios (ORs) for periodontitis were calculated for log-transformed blood metal levels and quartiles thereof after covariate adjustment.
In a logistic regression analysis using log-transformed blood lead and mercury levels as independent variables after covariate adjustment, including blood lead, mercury, and cadmium, the ORs and 95 % CI values in men for having periodontitis with doubling of blood lead and mercury were 1.699 (1.154-2.503) and 1.394 (1.057-1.838), respectively. Furthermore, in a logistic regression analysis using tertiles of blood lead and mercury as independent variables after covariate adjustment, the ORs and 95 % CIs of men for having periodontitis in the highest tertile were 1.756 (1.184-2.604) and 1.575 (1.507-2.347), respectively. ORs in the logistic regression analysis for men using log-transformed blood cadmium or the tertile of blood cadmium as independent variables after covariate adjustments were not statistically significant in either model. Unlike men, ORs in the logistic regression analyses for women using the same independent variables after covariate adjustment were not statistically significant in any blood metal analysis.
The association between blood lead and mercury levels and periodontitis was significant regardless of the type of variable (continuous or categorical) in the Korean male population.
我们呈现了 2008-2009 年韩国国家健康和营养检查调查的数据，该调查在韩国成年人代表性样本中研究了血液铅和汞水平与牙周炎之间的关系。
该分析仅限于完成健康检查调查的年龄≥20 岁的参与者，包括血液铅、镉和汞测量（n=3966）。在调整协变量后，使用对数转换的血液金属水平及其四分位数计算牙周炎的比值比（OR）。
在使用对数转换的血液铅和汞水平作为独立变量的逻辑回归分析中，在调整包括血液铅、汞和镉的协变量后，男性血液铅和汞水平翻倍时发生牙周炎的 OR 值和 95%CI 值分别为 1.699（1.154-2.503）和 1.394（1.057-1.838）。此外，在使用对数转换的血液铅和汞三分位数作为独立变量的逻辑回归分析中，调整协变量后，男性最高三分位数的牙周炎 OR 值和 95%CI 分别为 1.756（1.184-2.604）和 1.575（1.507-2.347）。在调整协变量后的逻辑回归分析中，男性血液镉或血液镉三分位数作为独立变量的 OR 值在两个模型中均无统计学意义。与男性不同，女性在调整协变量后的逻辑回归分析中，使用相同的独立变量的 OR 值在任何血液金属分析中均无统计学意义。
在韩国男性人群中，无论变量类型（连续或分类）如何，血液铅和汞水平与牙周炎之间均存在显著关联。
