UKK Institute for Health Promotion Research, Tampere, Finland.
Maturitas. 2013 Jul;75(3):241-5. doi: 10.1016/j.maturitas.2013.04.001. Epub 2013 Apr 30.
The number of hip fractures among Finns over 50-years of age rose constantly between 1970 and 1997, but since then, there has been a nationwide decline in incidence of hip fractures. One possible explanation, although not the only one, for the declining fracture rates, could be improved bone mineral density (BMD). The aim of this study was to evaluate differences in femoral neck BMD between older Finnish women born about a decade apart.
We compared the baseline data of two population-based samples of home-dwelling 70-80-year-old women who were initially recruited in exercise intervention studies (N=216 in Cohort1, and N=389 in Cohort 2). Femoral neck BMD was measured with DXA. Between-cohort differences were evaluated with analysis of covariance using age, height, weight, and use of hormone therapy as covariates.
The later-born Cohort 2 was somewhat older and taller than Cohort 1. Adjusted mean difference (95% CI) in femoral neck BMD between the cohorts was 0.043g/cm(2) (0.023-0.064) corresponding the mean difference of 0.36 (0.19-0.53) in T-score in favor of Cohort 2.
Despite several factors that basically could have indicated lower mean BMD in Cohort 2, the finding was the opposite. This suggests that the mean femoral neck BMD has increased substantially among older Finnish women within a decade, but primary reason for this improvement remains unclear, but improved social and economic resources may have at least partly accounted for this favorable phenomenon.
1970 年至 1997 年间,50 岁以上芬兰人的髋部骨折数量持续上升,但自那时以来,髋部骨折的发病率已呈全国性下降趋势。骨折率下降的一个可能原因(尽管不是唯一原因)是骨密度(BMD)的改善。本研究旨在评估 10 岁左右出生的老年芬兰女性股骨颈 BMD 之间的差异。
我们比较了两项基于人群的 70-80 岁居住在家庭中的女性的基线数据,这些女性最初是在运动干预研究中招募的(Cohort1 中为 216 人,Cohort2 中为 389 人)。使用 DXA 测量股骨颈 BMD。使用协方差分析,以年龄、身高、体重和激素治疗的使用为协变量,评估队列间差异。
出生较晚的 Cohort2 比 Cohort1 稍年长和更高。两个队列之间股骨颈 BMD 的调整平均差异(95%CI)为 0.043g/cm2(0.023-0.064),对应于 T 评分的平均差异为 0.36(0.19-0.53),有利于 Cohort2。
尽管有几个因素可能表明 Cohort2 的平均 BMD 较低,但结果却相反。这表明,在不到十年的时间里,芬兰老年女性的平均股骨颈 BMD 大幅增加,但这种改善的主要原因仍不清楚,但改善的社会和经济资源可能至少部分解释了这种有利现象。