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新生血管性年龄相关性黄斑变性:抗血管生成治疗时代的个体化治疗。

Neovascular age-related macular degeneration: individualizing therapy in the era of anti-angiogenic treatments.

出版信息

Ophthalmology. 2013 May;120(5 Suppl):S23-5. doi: 10.1016/j.ophtha.2013.01.059.

DOI:10.1016/j.ophtha.2013.01.059
PMID:23642783
Abstract

The treatment of neovascular age-related macular degeneration (AMD) had been revolutionized by the use of anti-vascular endothelial growth factor (VEGF) drugs: bevacizumab and ranibizumab. With the introduction of a third anti-VEGF drug, aflibercept, ophthalmologists have several options to choose from, as well as various treatment regimens they can follow. In this Interview, Jeffrey S. Heier, MD, of Ophthalmic Consultants of Boston, Massachusetts, discusses his approaches to managing the treatment of patients with AMD and providing them with individualized care.

摘要

抗血管内皮生长因子(VEGF)药物的应用彻底改变了新生血管性年龄相关性黄斑变性(AMD)的治疗:贝伐单抗和雷珠单抗。随着第三种抗 VEGF 药物阿柏西普的问世,眼科医生有了多种选择,以及他们可以遵循的各种治疗方案。在本次访谈中,来自马萨诸塞州波士顿眼科顾问公司的 Jeffrey S. Heier, MD 探讨了他在管理 AMD 患者的治疗和为他们提供个体化护理方面的方法。

相似文献

1
Neovascular age-related macular degeneration: individualizing therapy in the era of anti-angiogenic treatments.新生血管性年龄相关性黄斑变性:抗血管生成治疗时代的个体化治疗。
Ophthalmology. 2013 May;120(5 Suppl):S23-5. doi: 10.1016/j.ophtha.2013.01.059.
2
Efficacy and adverse events of aflibercept, ranibizumab and bevacizumab in age-related macular degeneration: a trade-off analysis.阿柏西普、雷珠单抗和贝伐单抗治疗年龄相关性黄斑变性的疗效及不良事件:一项权衡分析。
Br J Ophthalmol. 2015 Feb;99(2):141-6. doi: 10.1136/bjophthalmol-2014-305149. Epub 2014 Jun 11.
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Intravitreal aflibercept for neovascular age-related macular degeneration.玻璃体内注射阿柏西普治疗新生血管性年龄相关性黄斑变性。
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Switching anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration.转换抗血管内皮生长因子疗法治疗新生血管性年龄相关性黄斑变性。
Am J Ophthalmol. 2013 Jul;156(1):1-2.e1. doi: 10.1016/j.ajo.2013.04.009.
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Ranibizumab and aflibercept for the treatment of wet age-related macular degeneration.雷珠单抗和阿柏西普用于治疗湿性年龄相关性黄斑变性。
Expert Opin Biol Ther. 2015;15(9):1349-58. doi: 10.1517/14712598.2015.1057565. Epub 2015 Jun 16.
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Aflibercept for the treatment of neovascular age-related macular degeneration.阿柏西普用于治疗新生血管性年龄相关性黄斑变性。
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[Review and expert opinion in age related macular degeneration. Focus on the pathophysiology, angiogenesis and pharmacological and clinical data].[年龄相关性黄斑变性的综述与专家意见。聚焦于病理生理学、血管生成以及药理学和临床数据]
J Fr Ophtalmol. 2014 Sep;37(7):566-79. doi: 10.1016/j.jfo.2014.06.001. Epub 2014 Sep 1.
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Treating age-related macular degeneration - interaction of VEGF-antagonists with their target.治疗年龄相关性黄斑变性——血管内皮生长因子拮抗剂与其靶点的相互作用
Mini Rev Med Chem. 2009 Aug;9(9):1127-35. doi: 10.2174/138955709788922665.
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VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration.阿柏西普眼内注射溶液用于治疗新生血管性年龄相关性黄斑变性。
Expert Opin Investig Drugs. 2009 Oct;18(10):1573-80. doi: 10.1517/13543780903201684.
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Current anti-vascular endothelial growth factor dosing regimens: benefits and burden.当前抗血管内皮生长因子给药方案:获益与负担。
Ophthalmology. 2013 May;120(5 Suppl):S3-7. doi: 10.1016/j.ophtha.2013.01.057.

引用本文的文献

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Conversion back to bevacizumab or ranibizumab for recurrent neovascular activity with aflibercept in age-related macular degeneration: a case series.在年龄相关性黄斑变性中,对于使用阿柏西普后出现新生血管活动复发的情况,重新转换为贝伐单抗或雷珠单抗治疗:病例系列
Int J Retina Vitreous. 2016 Jan 25;2:2. doi: 10.1186/s40942-016-0028-9. eCollection 2016.
2
Estimating cumulative pathway effects on risk for age-related macular degeneration using mixed linear models.使用混合线性模型估计年龄相关性黄斑变性风险的累积通路效应。
BMC Bioinformatics. 2015 Oct 14;16:329. doi: 10.1186/s12859-015-0760-4.
3
Management of neovascular age-related macular degeneration: current state-of-the-art care for optimizing visual outcomes and therapies in development.
新生血管性年龄相关性黄斑变性的管理:优化视觉效果的当前先进治疗方法及正在研发的疗法
Clin Ophthalmol. 2015 Jun 5;9:1001-15. doi: 10.2147/OPTH.S74959. eCollection 2015.
4
Optical coherence tomographic and visual results at six months after transitioning to aflibercept for patients on prior ranibizumab or bevacizumab treatment for exudative age-related macular degeneration (an American Ophthalmological Society thesis).对于先前接受雷珠单抗或贝伐单抗治疗渗出性年龄相关性黄斑变性的患者,转换为阿柏西普治疗6个月后的光学相干断层扫描和视力结果(美国眼科学会论文)
Trans Am Ophthalmol Soc. 2014 Jul;112:160-98.
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Screening of antiangiogenic potential of twenty two marine invertebrate extracts of phylum Mollusca from South East Coast of India.对来自印度东南海岸的22种软体动物门海洋无脊椎动物提取物的抗血管生成潜力进行筛选。
Asian Pac J Trop Biomed. 2014 May;4(Suppl 1):S129-38. doi: 10.12980/APJTB.4.2014C701.