Forner Giner J, Sanz-Requena R, Flórez N, Alberich-Bayarri A, García-Martí G, Ponz A, Martí-Bonmatí L
Servicio de Radiología, Hospital Quirón Valencia, Valencia, España.
Servicio de Radiología, Hospital Quirón Valencia, Valencia, España.
Neurologia. 2014 Mar;29(2):68-75. doi: 10.1016/j.nrl.2013.02.016. Epub 2013 May 3.
The aim of this study is to evaluate the use of phase-contrast MR imaging to diagnose normal pressure hydrocephalus (NPH) and differentiate it from other neurological disorders with similar clinical symptoms.
The study included 108 subjects, of whom 61 were healthy controls and 47, patients; in the patient group, 19 had cerebrovascular disease (CVD) and 28 had NPH. All patients underwent a phase-contrast MRI study and several CSF flow and velocity parameters were measured at the aqueduct of Sylvius. Discriminant analyses were performed to evaluate the classification capacity of both individual parameters and the combination of different parameters.
Maximum diastolic velocity, mean flow, and stroke volume showed statistically significant differences that could be used to distinguish between NPH and CVD patients (P<.001). Stroke volume and mean flow showed no false positive results and successful classification rates of 86% and 79%, respectively. No other parameters or combination produced better results.
Phase-contrast MR imaging is a useful tool for the early diagnosis of patients with NPH. CSF flow quantitative parameters, along with morphological features in a conventional MR study, enable us to differentiate between NPH and CVD patients.
本研究旨在评估相位对比磁共振成像用于诊断正常压力脑积水（NPH）并将其与具有相似临床症状的其他神经系统疾病相鉴别的应用价值。
该研究纳入108名受试者，其中61名为健康对照者，47名为患者；患者组中，19例患有脑血管疾病（CVD），28例患有NPH。所有患者均接受了相位对比磁共振成像研究，并在中脑导水管测量了多个脑脊液流动和速度参数。进行判别分析以评估各个参数及不同参数组合的分类能力。
舒张末期最大流速、平均流量和每搏量显示出具有统计学意义的差异，可用于区分NPH患者和CVD患者（P<0.001）。每搏量和平均流量未出现假阳性结果，成功分类率分别为86%和79%。没有其他参数或参数组合能产生更好的结果。
相位对比磁共振成像是早期诊断NPH患者的有用工具。脑脊液流动定量参数以及传统磁共振研究中的形态学特征，使我们能够区分NPH患者和CVD患者。
