Federal Fluminense University, Graduate Programme in Cardiovascular Sciences, Niterói-RJ, Brazil.
Biochimie. 2013 Aug;95(8):1525-33. doi: 10.1016/j.biochi.2013.04.012. Epub 2013 May 1.
The nuclear factor E2-related factor 2 (Nrf2) plays an important role in cellular protection against cancer, renal, pulmonary, cardiovascular and neurodegenerative diseases where oxidative stress and inflammation are common conditions. The Nrf2 regulates the expression of detoxifying enzymes by recognizing the human Antioxidant Response Element (ARE) binding site and it can regulate antioxidant and anti-inflammatory cellular responses, playing an important protective role on the development of the diseases. Studies designed to investigate how effective Nrf2 activators or modulators are need to be initiated. Several recent studies have shown that nutritional compounds can modulate the activation of Nrf2-Keap1 system. This review aims to discuss some of the key nutritional compounds that promote the activation of Nrf2, which may have impact on the human health.
核因子 E2 相关因子 2（Nrf2）在细胞保护方面发挥着重要作用，可对抗癌症、肾脏、肺部、心血管和神经退行性疾病，这些疾病的共同特征是氧化应激和炎症。Nrf2 通过识别人类抗氧化反应元件（ARE）结合位点来调节解毒酶的表达，它可以调节抗氧化和抗炎细胞反应，在疾病的发展过程中发挥重要的保护作用。需要启动旨在研究 Nrf2 激活剂或调节剂有效性的研究。最近的几项研究表明，营养化合物可以调节 Nrf2-Keap1 系统的激活。本综述旨在讨论一些促进 Nrf2 激活的关键营养化合物，这些化合物可能对人类健康产生影响。
