Department of Neurology, Chinese PLA General Hospital, Beijing 100853, PR China.
Neurosci Lett. 2013 Sep 13;551:1-6. doi: 10.1016/j.neulet.2013.04.038. Epub 2013 May 2.
The comorbidity between migraine and depression not only provides a major treatment challenge, but also represents a heavy burden on society. However, the relationship between depression and migraine and their molecular biological mechanisms remain unclear. This study investigated the effects of depression elicited by unpredictable chronic mild stress (UCMS) on trigeminovascular nociception in conscious rats and detected a concentration of calcitonin gene-related peptide (CGRP) and substance P (SP) in the external jugular vein. We divided the rats into four groups: control-stimulated (C/S), control-nonstimulated (C/NS), UCMS-stimulated (U/S), and UCMS-nonstimulated (U/NS). We stimulated the dura mater adjacent to the superior sagittal sinus of rats in the C/S and U/S groups and observed their nociceptive behaviors. We found significant differences between the UCMS and control groups in weight, sucrose preference, and locomotor behavior. Nociceptive behaviors (number of head flicks and head-turning time) were significantly increased in the U/S compared with the C/S group, and head-turning time correlated with depressive-like behaviors. The plasma level of SP was increased significantly in the U/NS compared with the C/NS group. However, no significant differences involving the other groups were observed. UCMS-induced depression can exacerbate trigeminovascular nociception, making rats more sensitive to pain.
偏头痛和抑郁症的共病不仅带来了重大的治疗挑战，也给社会带来了沉重的负担。然而，抑郁症与偏头痛之间的关系及其分子生物学机制仍不清楚。本研究探讨了不可预测性慢性轻度应激（UCMS）诱发的抑郁症对清醒大鼠三叉血管伤害感受的影响，并检测了颈外静脉中降钙素基因相关肽（CGRP）和 P 物质（SP）的浓度。我们将大鼠分为四组：对照组刺激（C/S）、对照组非刺激（C/NS）、UCMS 刺激（U/S）和 UCMS 非刺激（U/NS）。我们刺激 C/S 和 U/S 组大鼠上矢状窦旁硬脑膜，并观察它们的伤害感受行为。我们发现 UCMS 组与对照组在体重、蔗糖偏好和运动行为方面存在显著差异。与 C/S 组相比，U/S 组的伤害感受行为（头摆动次数和头转动时间）显著增加，头转动时间与抑郁样行为相关。与 C/NS 组相比，U/NS 组 SP 血浆水平显著升高。然而，其他组之间没有观察到显著差异。UCMS 诱导的抑郁症可加重三叉血管伤害感受，使大鼠对疼痛更敏感。
