Yang G, Zhang L, Fan L
Second Clinical College of Bethune Medical University, Changchun.
Zhong Xi Yi Jie He Za Zhi. 1990 Feb;10(2):82-4, 68.
Plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandin Fl alpha(6-K-PGFl alpha), the stable nonenzymatic metabolites of TXA2 and prostacyclin were assayed in 30 patients suffering from angina pectoris before and after administration of puerarin. In addition, serum lipids and HDL were also measured at the same time. 20 healthy subjects were chosen as the control group. Two weeks before and during administration of puerarin, aspirin, calcium-antagonists, all kinds of hypotensors and drugs relieving chest pain of angina pectoris were strictly prohibited. Puerarin was intravenously given, 500 mg daily for 7 days, which was considered as a therapeutic course. Besides relieving of chest pain, decreasing of heart rate and reduction of blood pressure clinically, it was also found that plasma 6-K-PGFl alpha concentrations were significantly elevated from 38.32 +/- 15.40 to 158. 79 +/- 98.62 pg (P less than 0.01) after administration of puerarin, but there was no significantly difference between plasma TXB2 concentrations before and after administering the drug. In addition, serum HDL was apparently enhanced as compared with that before the administration of puerarin (P less than 0.01). The results indicated that puerarin has the function of anti-angina, reducing both systolic and diastolic blood pressure and diminishing myocardial oxygen consumption.
对30例心绞痛患者在服用葛根素前后检测血浆血栓素B2（TXB2）和6-酮-前列腺素F1α（6-K-PGF1α）的浓度，二者分别是血栓素A2（TXA2）和前列环素的稳定非酶代谢产物。此外，同时测定血脂和高密度脂蛋白（HDL）。选取20名健康受试者作为对照组。在服用葛根素前两周及服药期间，严格禁止使用阿司匹林、钙拮抗剂、各类降压药及缓解心绞痛胸痛的药物。葛根素采用静脉给药，每日500mg，连用7天，视为一个疗程。除临床上缓解胸痛、降低心率和血压外，还发现服用葛根素后血浆6-K-PGF1α浓度从38.32±15.40显著升高至158.79±98.62pg（P<0.01），但给药前后血浆TXB2浓度无显著差异。此外，与服用葛根素前相比，血清HDL明显升高（P<0.01）。结果表明，葛根素具有抗心绞痛、降低收缩压和舒张压以及减少心肌耗氧量的作用。
