Reza Md Alimoor, Mhatre Siddhita D, Morrison J Calvin, Utreja Suruchi, Saunders Aleister J, Breen David E, Marenda Daniel R
Department of Computer Science, Drexel University, Philadelphia, PA, USA.
Fly (Austin). 2013 Apr-Jun;7(2):105-11. doi: 10.4161/fly.24110. Epub 2013 Apr 1.
Study of the fruit fly, Drosophila melanogaster, has yielded important insights into the underlying molecular mechanisms of learning and memory. Courtship conditioning is a well-established behavioral assay used to study Drosophila learning and memory. Here, we describe the development of software to analyze courtship suppression assay data that correctly identifies normal or abnormal learning and memory traits of individual flies. Development of this automated analysis software will significantly enhance our ability to use this assay in large-scale genetic screens and disease modeling. The software increases the consistency, objectivity, and types of data generated.
对果蝇黑腹果蝇的研究已经为学习和记忆的潜在分子机制提供了重要见解。求偶条件反射是一种成熟的行为检测方法，用于研究果蝇的学习和记忆。在这里，我们描述了一种软件的开发，该软件用于分析求偶抑制检测数据，能够正确识别个体果蝇的正常或异常学习和记忆特征。这种自动化分析软件的开发将显著提高我们在大规模基因筛选和疾病建模中使用该检测方法的能力。该软件提高了所生成数据的一致性、客观性和类型。
