The Mina & Everard Goodman Faculty of Life Sciences, The Nanotechnology Institute, Bar-Ilan University, Ramat Gan, Israel.
Lab Chip. 2013 Jun 21;13(12):2202-9. doi: 10.1039/c3lc00034f. Epub 2013 May 3.
Viral-host interactions represent potential drug targets for novel antiviral strategies (Flisiak et al., Hepatology, 2008, 47, 817-26). Hence, it is important to establish an adequate platform for identifying and analyzing such interactions. In this review, we discuss bottlenecks in conventional protein-protein interaction methodologies and present the contribution of innovative microfluidic-based technologies towards a solution to these problems with respect to viral-host proteomics.
病毒-宿主相互作用是新型抗病毒策略的潜在药物靶点（Flisiak 等人，《肝脏病学》，2008 年，47 卷，817-26）。因此，建立一个合适的平台来识别和分析这种相互作用非常重要。在这篇综述中，我们讨论了传统蛋白质-蛋白质相互作用方法学中的瓶颈，并介绍了创新的基于微流控技术在解决病毒-宿主蛋白质组学方面的这些问题方面的贡献。
