Rush University Medical Center, 600 S Paulina Ste 140, Chicago, IL 60612, USA.
Curr HIV/AIDS Rep. 2013 Sep;10(3):244-53. doi: 10.1007/s11904-013-0161-0.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has emerged as an increasingly important pathogen, causing infections in persons who have no significant healthcare exposures. Persons with human immunodeficiency virus (HIV) infection have been disproportionately affected by CA-MRSA, with increased colonization and infection documented. Several factors are likely involved in the increased CA-MRSA burden observed among HIV-infected patients, including immune factors as well as healthcare and community exposures. Proposed community exposures that have been associated with increased CA-MRSA risk include substance abuse, incarceration, geographic area of residence, and social networks. This article explores these associations and reviews the current knowledge of the epidemiology, pathogenesis, clinical manifestations, and treatment of CA-MRSA in HIV-infected persons.
社区相关性耐甲氧西林金黄色葡萄球菌（CA-MRSA）已成为一种日益重要的病原体，可导致无明显医疗暴露史的人群发生感染。人类免疫缺陷病毒（HIV）感染者受到 CA-MRSA 的不成比例影响，已有大量定植和感染的记录。HIV 感染者中观察到的 CA-MRSA 负担增加可能涉及多种因素，包括免疫因素以及医疗保健和社区暴露。与 CA-MRSA 风险增加相关的拟议社区暴露包括药物滥用、监禁、居住地区和社交网络。本文探讨了这些关联，并综述了 HIV 感染者中 CA-MRSA 的流行病学、发病机制、临床表现和治疗的现有知识。
