Breast unit, Department of Medical Oncology, Oscar Lambret Center, Lille Cedex, France.
Anticancer Res. 2013 May;33(5):2057-63.
BACKGROUND/AIM: Prolonged overall survival (OS) has been reported for selected patients with leptomeningeal metastases (LM). The management and treatment of such patients is poorly-described. We report our experience on breast cancer (BC)-associated LM and patients with prolonged survival.
Eleven patients with BC and LM had an OS >12 months in which treatment is described.
Combined intra-cerebro spinal fluid (CSF) and systemic treatment were administered until disease progression or toxicity in all but two patients. Involved-field radiotherapy was administered to two patients. Median OS in this selected cohort following LM diagnosis, was 21.0 (range=13-33.3) months.
Prolonged OS but also prolonged responses can be observed in BC with LM. An individualized and multi-disciplinary approach is advised for the management of these patients.
背景/目的：有研究报道，对于某些脑膜转移（LM）患者，其总体生存期（OS）较长。但此类患者的管理和治疗方法尚未明确。我们报告了乳腺癌（BC）相关 LM 患者和生存期较长患者的经验。
11 例 OS 超过 12 个月的 BC 合并 LM 患者的治疗情况在文中均有描述。
除了 2 例患者外，其余患者均接受了联合脑脊髓液（CSF）和全身治疗，直到疾病进展或出现毒性。2 例患者接受了累及野放疗。在该选定队列中，从诊断为 LM 开始，中位 OS 为 21.0（范围=13-33.3）个月。
在 BC 合并 LM 的患者中，可观察到较长的 OS 和较长的缓解期。建议对这些患者采取个体化和多学科的管理方法。
