Hachem Ali, Nandi Suvobroto
The Cancer Center of Huntsville, Huntsville, AL 35801.
Transl Oncogenomics. 2007 Jul 19;2:79-84. Print 2007.
The oncogene MCTS1, discovered as an amplified product in a subset of T-cell lymphoma lines, has been implicated in cell cycle progression and conferring a growth advantage in lymphomas and breast cancer. Recent research shows that it modulates the MAPK pathway and acts as a translational activator both in vivo and in vitro. In breast cancer cells, expression of MCTS1 confers aggressive properties and inhibits apoptosis. This article will review these data and its implications on our understanding of cancer.
癌基因MCTS1最初是在一部分T细胞淋巴瘤细胞系中作为扩增产物被发现的，它与细胞周期进程有关，并赋予淋巴瘤和乳腺癌生长优势。最近的研究表明，它能调节丝裂原活化蛋白激酶（MAPK）信号通路，在体内和体外均作为翻译激活因子发挥作用。在乳腺癌细胞中，MCTS1的表达赋予细胞侵袭性并抑制细胞凋亡。本文将综述这些数据及其对我们理解癌症的意义。
