Xin-Xin Chen, Yu-Xian Cheng
Department of Pediatrics, Liaocheng People's Hospital, Shandong (252000), China
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):155-8.
To observe the effects of Xingpi Yang'er Granule (XYG) on serum gastrin (GAS), plasma motilin (MOT), and somatostatin (SS) in children patients with pneumonia induced diarrhea.
Recruited were 120 children inpatients with pneumonia induced diarrhea at the Department of Pediatrics, Liaocheng People's Hospital from June 2011 to June 2012. They were randomly assigned to two groups, the treatment group and the control group, 60 in each group. Those in the treatment group were treated with XYG, while those in the control group were treated with Live Combined Bifidobacterium and Lactobacillus Tablets. Besides, 30 healthy children who received physical examinations at our hospital were recruited as the healthy control group. The clinical efficacy, changes of GAS, MOT, and SS contents were observed.
The total effective rate was 95.0% in the treatment group and 93.3% in the control group, showing no statistical difference (P > 0.05). Compared with healthy control group, the GAS and MOT contents increased, and SS decreased before treatment in the other two groups (P < 0.05). Compared with the same group before treatment, GAS and MOT contents obviously decreased, and SS increased in the other two groups after treatment (P<0.05). Compared with the control group at the same time point, GAS and MOT decreased, and SS increased in the treatment group after treatment, showing statistical differences (P < 0.05).
The levels of GAS, MOT, and SS were obviously changed in children patients with pneumonia induced diarrhea. XYG had obvious regulation on their GAS, MOT and SS contents.
观察醒脾养儿颗粒（XYG）对肺炎并腹泻患儿血清胃泌素（GAS）、血浆胃动素（MOT）及生长抑素（SS）的影响。
选取2011年6月至2012年6月聊城市人民医院儿科住院的肺炎并腹泻患儿120例，随机分为治疗组和对照组，每组60例。治疗组给予醒脾养儿颗粒治疗，对照组给予双歧杆菌四联活菌片治疗。另外，选取在我院进行体检的30例健康儿童作为健康对照组。观察临床疗效及GAS、MOT、SS含量变化。
治疗组总有效率为95.0%，对照组为93.3%，差异无统计学意义（P>0.05）。与健康对照组比较，治疗前其他两组GAS、MOT含量升高，SS含量降低（P<0.05）。与治疗前同组比较，治疗后其他两组GAS、MOT含量明显降低，SS含量升高（P<0.05）。治疗后治疗组与对照组同时点比较，GAS、MOT降低，SS升高，差异有统计学意义（P<0.05）。
肺炎并腹泻患儿GAS、MOT、SS水平明显改变，醒脾养儿颗粒对其GAS、MOT、SS含量有明显调节作用。
