头孢呋辛酯联合醒脾养儿颗粒对伴腹泻的上呼吸道感染患儿血清胃泌素、胃动素及生长抑素水平的影响：一项随机试验的结果

Effects of cefuroxime axetil combined with Xingpi Yanger granules on the serum gastrin, motilin, and somatostatin levels in children with upper respiratory tract infection accompanied by diarrhea: results of a randomized trial.

作者信息

Ren Xiaohong, Wang Yuying, He Zimeng, Liu Hongli, Xue Kun

机构信息

The Fifth Department of Pediatrics, Baoji Maternal and Child Health Hospital, Baoji, China.

The Second Department of Pediatrics, Baoji Maternal and Child Health Hospital, Baoji, China.

出版信息

Transl Pediatr. 2021 Aug;10(8):2106-2113. doi: 10.21037/tp-21-314.

DOI:10.21037/tp-21-314

PMID:34584881

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8429862/

Abstract

BACKGROUND

The purpose of the study was to investigate the effects of cefuroxime axetil combined with Xingpi Yanger granules on the treatment of upper respiratory tract infection accompanied by diarrhea and on serum gastrin (GAS), motilin (MOT), and somatostatin (SS) levels in children.

METHODS

In total, 124 children with upper respiratory tract infection accompanied by diarrhea admitted to the department of pediatrics in our hospital from May 2019 to May 2020 were selected and divided into a study group (n=62) and a reference group (n=62), according to admission number. The reference group children received routine treatment, while the children in the study group were treated with cefuroxime axetil combined with Xingpi Yanger granules. After treatment, each clinical index of the children in both groups was detected to evaluate the clinical efficacy of the different treatment methods.

RESULTS

There were no significant differences in gender ratio, average age, mean body temperature, mean duration of diarrhea, average weight, or place of residence between the 2 groups (P>0.05); the total clinical effective rate after treatment in the study group was significantly higher than that in the reference group (P<0.05); the dehydration correction time, antipyretic time, antidiarrheal time, and total treatment time in the study group were all significantly lower than those in the reference group (P<0.001); the serum GAS and MOT levels at T1, T2, and T3 in the study group were significantly lower than those in the reference group (P<0.001), whereas the SS levels at T1, T2, and T3 in the study group were significantly higher than those in the reference group (P<0.001); and the incidence of adverse reactions of the children in the study group was significantly lower than that in the reference group (P<0.05).

CONCLUSIONS

Cefuroxime axetil combined with Xingpi Yanger granules can significantly lower serum GAS, MOT, and SS levels and shorten treatment time in children with upper respiratory tract infection accompanied by diarrhea, with significant clinical efficacy and high safety, and is thus worthy of application and promotion.

TRIAL REGISTRATION

Chinese Clinical Trial Registry ChiCTR2100049234.

摘要

背景

本研究旨在探讨头孢呋辛酯联合醒脾养儿颗粒治疗上呼吸道感染伴腹泻患儿的疗效及对血清胃泌素（GAS）、胃动素（MOT）和生长抑素（SS）水平的影响。

方法

选取2019年5月至2020年5月我院儿科收治的124例上呼吸道感染伴腹泻患儿，按入院顺序分为研究组（n = 62）和参照组（n = 62）。参照组患儿接受常规治疗，研究组患儿采用头孢呋辛酯联合醒脾养儿颗粒治疗。治疗后，检测两组患儿各项临床指标，评估不同治疗方法的临床疗效。

结果

两组患儿性别比例、平均年龄、平均体温、平均腹泻时长、平均体重及居住地等方面比较，差异均无统计学意义（P > 0.05）；研究组治疗后总临床有效率显著高于参照组（P < 0.05）；研究组脱水纠正时间、退热时间、止泻时间及总治疗时间均显著短于参照组（P < 0.001）；研究组T1、T2、T3时血清GAS和MOT水平显著低于参照组（P < 0.001），而T1、T2、T3时血清SS水平显著高于参照组（P < 0.001）；研究组患儿不良反应发生率显著低于参照组（P < 0.05）。