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从“湿热疫毒”到“癌毒”探索肝癌的发病机制与治疗

[Exploring the pathogenesis and therapy of liver cancer from "damp-heat insidious pathogen" to "cancer toxin"].

作者信息

Wang Shu-Jie, Wei Ai-Ling

机构信息

Department of Liver Disease, Chinese Medicine Hospital of Liuyang City, Hunan (410300), China.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Feb;33(2):266-9.

PMID:23646487
Abstract

From a macro-level analysis of the attributes and pathogenic features of HBV, the main pathogenic factor for chronic liver diseases including viral hepatitis, cirrhosis, and liver cancer, the concept of damp-heat insidious pathogen was obtained, according to which, in-depth discussions were undertaken. Adopting syndrome typing of Wei (defense), qi (vital energy), Ying (nutrients), and blood, the pathogens leading to different syndromes as well as new products such as pathological "sputum", "stasis" in the disease process were understood, and then, the pathological "sputum" and "stasis", as the hub, playing a role in chronic lesions of the liver collateral were explained. Finally the pathological "sputum" and "stasis" blend and form cancer toxin. Through a comprehensive understanding of the development of chronic liver diseases, it is clear that damp-heat insidious pathogen, as its initiating factor, always exists in the whole process. We summed up heat clearing, dampness resolving, and detoxification was the principle for treating chronic liver disease.

摘要

通过对慢性肝病(包括病毒性肝炎、肝硬化和肝癌)的主要致病因素——乙肝病毒的属性及致病特点进行宏观层面的分析,得出了湿热疫毒的概念,并据此展开了深入探讨。采用卫气营血辨证,了解导致不同证型的病邪以及疾病过程中出现的病理产物如“痰”“瘀”等,进而阐述了以病理产物“痰”“瘀”为枢纽在肝络慢性病变中的作用。最后病理“痰”“瘀”胶结形成癌毒。通过对慢性肝病发展过程的全面认识,明确湿热疫毒作为起始因素始终存在于整个过程中。我们总结出清热化湿解毒是治疗慢性肝病的原则。

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