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一名癌症临终关怀患者使用极高剂量美沙酮，毒性极小但疼痛控制不佳。

Very-high-dose methadone with minimal toxicity and inadequate pain control in a hospice patient with cancer.

作者信息

Latuga Natalie M, Wahler Robert G

机构信息

The Center for Hospice and Palliative Care, 225 Como Park Boulevard, Cheektowaga, NY 14227, USA.

出版信息

J Pain Palliat Care Pharmacother. 2013 Jun;27(2):143-9. doi: 10.3109/15360288.2013.786011. Epub 2013 May 6.

DOI:10.3109/15360288.2013.786011
PMID:23646910
Abstract

A case is reported of a 48-year-old Caucasian male who was admitted to hospice care with metastatic cancer of the larynx. The patient required very high methadone doses and experienced little opioid toxicity. The pharmacodynamics and pharmacokinetics of methadone are discussed in the context of this patient experience.

摘要

报告了一例48岁的高加索男性患者，因喉转移性癌入住临终关怀病房。该患者需要非常高剂量的美沙酮，且几乎没有出现阿片类药物毒性。结合该患者的经历对美沙酮的药效学和药代动力学进行了讨论。

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