Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA 16802, USA.
Anal Chem. 2013 Jun 4;85(11):5468-74. doi: 10.1021/ac400548d. Epub 2013 May 23.
The emerging field of droplet microfluidics requires effective on-chip handling and sorting of droplets. In this work, we demonstrate a microfluidic device that is capable of sorting picoliter water-in-oil droplets into multiple outputs using standing surface acoustic waves (SSAW). This device integrates a single-layer microfluidic channel with interdigital transducers (IDTs) to achieve on-chip droplet generation and sorting. Within the SSAW field, water-in-oil droplets experience an acoustic radiation force and are pushed toward the acoustic pressure node. As a result, by tuning the frequency of the SSAW excitation, the position of the pressure nodes can be changed and droplets can be sorted to different outlets at rates up to 222 droplets s(-1). With its advantages in simplicity, controllability, versatility, noninvasiveness, and capability to be integrated with other on-chip components such as droplet manipulation and optical detection units, the technique presented here could be valuable for the development of droplet-based micro total analysis systems (μTAS).
新兴的液滴微流控领域需要有效地在芯片上处理和分选液滴。在这项工作中,我们展示了一种微流控器件,该器件能够使用驻波表面声波(SSAW)将皮升级的油包水液滴分选到多个出口。该器件集成了单层微流道和叉指换能器(IDT),以实现芯片上的液滴生成和分选。在 SSAW 场中,油包水液滴会受到声辐射力的作用,并被推向声压节点。因此,通过调整 SSAW 激励的频率,可以改变压力节点的位置,从而以高达 222 个液滴 s(-1)的速度将液滴分选到不同的出口。由于其具有简单、可控、多功能、非侵入性以及与其他芯片组件(如液滴操作和光学检测单元)集成的能力,这里提出的技术对于开发基于液滴的微全分析系统(μTAS)可能具有重要价值。