Zhou Yiming, Cui Zhenling, Zhou Xiao, Chen Chang, Jiang Sen, Hu Zhongyi, Jiang Gening
Department of Thoracic Surgery, Tongji University School of Medicine, Shanghai, China.
J Cardiothorac Surg. 2013 May 6;8:123. doi: 10.1186/1749-8090-8-123.
Pulmonary tuberculosis (TB) is associated with an increased risk of lung cancer. Our study investigated whether the coexistence of an old pulmonary TB lesion is an independent prognostic factor for lung cancer survival in Chinese non-small cell lung cancer patients.
We performed a retrospective review of 782 non-small cell lung cancer patients who underwent surgical resection as their primary treatment in 2006 and were followed for 5 years. The associations between lung cancer survival and the presence of old pulmonary TB lesions were assessed using Cox's proportional hazard regression analysis adjusted for WHO performance status (PS), age, sex, smoking-status, tumor stage, and surgical approach.
Sixty-four of the patients had old pulmonary TB lesions. The median survival of squamous cell carcinoma patients with TB was significantly shorter than that of patients without TB (1.7 vs. 3.4 years, p < 0.01). The presence of an old pulmonary TB lesion is an independent predictor of poor survival with a hazard ratio (HR) of 1.72 (95% CI, 1.12-2.64) in the subgroup of squamous cell carcinoma patients studied.
The presence of an old pulmonary TB lesion may be an important prognostic factor for predicting the survival of squamous cell carcinoma patients.
肺结核（TB）与肺癌风险增加相关。我们的研究调查了陈旧性肺结核病灶的共存是否是中国非小细胞肺癌患者肺癌生存的独立预后因素。
我们对2006年接受手术切除作为主要治疗且随访5年的782例非小细胞肺癌患者进行了回顾性研究。使用经世界卫生组织表现状态（PS）、年龄、性别、吸烟状态、肿瘤分期和手术方式校正的Cox比例风险回归分析评估肺癌生存与陈旧性肺结核病灶存在之间的关联。
64例患者有陈旧性肺结核病灶。有结核的鳞状细胞癌患者的中位生存期显著短于无结核患者（1.7年对3.4年，p<0.01）。在所研究的鳞状细胞癌患者亚组中，陈旧性肺结核病灶的存在是生存不良的独立预测因素，风险比（HR）为1.72（95%CI，1.12 - 2.64）。
陈旧性肺结核病灶的存在可能是预测鳞状细胞癌患者生存的重要预后因素。
